نتایج جستجو برای: hepatotoxic effect
تعداد نتایج: 1642793 فیلتر نتایج به سال:
A novel series of 6-chlorotacrine-scutellarin hybrids was designed, synthesized and the biological activity as potential anti-Alzheimer's agents was assessed. Their inhibitory activity towards human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), antioxidant activity, ability to cross the blood-brain barrier (BBB) and hepatotoxic profile were evaluated in vitro. Among thes...
Herbal and dietary supplement usage has increased steadily over the past several years in the United States. Among the non-bodybuilding herbal and dietary supplements, weight loss supplements were among the most common type of HDS implicated in liver injury. While drug induced liver injury is rare, its consequences are significant and on the rise. The purpose of this review is to highlight case...
The case of a 64 year old female patient is presented who has treated herself for 9 months with various Indian Ayurvedic herbal products for her vitiligo and experienced a causally related severe hepatotoxicity (ALT, 601 U/L; AST, 663 U/L; Bilirubin, 5.0 mg/dL). After discontinuation, a rapid improvement was observed. Causality assessment with the updated CIOMS (Council for International Organi...
Objective. Develop an experimental model of liver cirrhosis and describe pathomorphological changes in organs tissues laboratory animals. Materials methods. Liver was simulated on 11 sexually mature Wistar male white rats. The control group consisted 12 healthy Acute toxic injury resulting induced by intraperitoneal injection 50% tetrachloromethane (CCl 4 ) solution olive oil the first day expe...
The Spheroid Reservoir Bioartificial Liver (SRBAL) is an innovative treatment option for acute liver failure (ALF). This extracorporeal support device, which provides detoxification and other functions using high-density culture of porcine hepatocyte spheroids, has been reported in three randomized large animal studies. A meta-analysis these preclinical studies was performed to establish effica...
Statins have been used in clinical practice for more than a quarter of century. Over this period, their positions various guidelines significantly strengthened. First, group drugs was exclusively the treatment patients with pronounced increase levels atherogenic lipoproteins, but over time, indications prescription expanded considerably as well tactics use. The aim our work is to determine effe...
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