نتایج جستجو برای: hereditary breast cancer
تعداد نتایج: 1055993 فیلتر نتایج به سال:
In India the incidence of breast cancer is on the rise and it is rapidly becoming the number one cancer in females, pushing cervical cancer to the second spot. The contribution of BRCA2 to the development of the sporadic form of breast cancer remains undefined. To assess the role of SNPs in exon 8 of the BRCA2 gene in breast cancer development in India, a population-based study was here carried...
In Latin America, breast cancer is the most common malignancy in women, and limited available data suggest that up to 15% of all breast cancer cases in the region are hereditary. Genetic cancer risk assessment and counseling is a critical component of the appropriate clinical care of patients with hereditary breast cancer and their families. Unfortunately, genetic services are underdeveloped ac...
How useful are hereditary cancer susceptibility syndromes for modeling sporadic cancers? If the biology of cancers developing within hereditary syndromes follows the same pathways to malignancy as does a substantial proportion of sporadic cancers, then prevention trials focused on hereditary high-risk individuals can lead to important gains in the sporadic setting. McKusick struggled with this ...
OBJECTIVE Hereditary cancer testing guidelines are based on the premise that the common hereditary cancer syndromes have distinct, recognizable phenotypes. However, many syndromes present with overlapping cancers. The aim of this analysis was to identify the proportion of patients tested for Lynch syndrome (LS) or hereditary breast and ovarian cancer (HBOC) who met testing criteria for the othe...
How useful are hereditary cancer susceptibility syndromes for modeling sporadic cancers? If the biology of cancers developing within hereditary syndromes follows the same pathways to malignancy as does a substantial proportion of sporadic cancers, then prevention trials focused on hereditary high-risk individuals can lead to important gains in the sporadic setting. McKusick struggled with this ...
CONTEXT Hereditary diffuse gastric cancer is caused by germline mutations in the epithelial cadherin (CDH1) gene and is characterized by an increased risk for diffuse gastric cancer and lobular breast cancer. OBJECTIVE To determine whether recurring germline CDH1 mutations occurred due to independent mutational events or common ancestry. DESIGN, SETTING, AND PATIENTS Thirty-eight families d...
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths (Jemal et al., 2011). Breast cancer is now also the leading cause of cancer death among females in economically developing countries, a shift from the previous decade during which the most common cause of cancer deat...
Previous studies have determined that the frequency of germ-line p53 mutations in familial breast cancer patients is 1% or less, but these reports have not investigated the importance of polymorphic intron base changes in the p53 gene. Therefore, we investigated the frequency of both exon and intron germ-line p53 base changes in 42 breast cancer patients with a strong family history of breast c...
The history of specific therapy for hereditary tumors dates back to mid 1980s and involves a number of reports demonstrating regression of familial colon polyps upon administration of sulindac. Virtually no clinical studies on other hereditary cancer types were available until the year 2009, when Byrski et al. presented the data on unprecedented sensitivity of BRCA1-associated breast malignanci...
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