Hot Melt Extrusion (HME) is well known process for the Plastic Industries but it is well accepted by the pharmaceutical industries for the last three decays. With the use of HME we can increase solubility and bio-availability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and targeted drug delivery systems.HME is a solvent ...

BACKGROUND Human monocytic ehrlichiosis (HME) and Rocky Mountain spotted fever (RMSF) are caused by Ehrlichia chaffeensis and Rickettsia rickettsii, respectively. The pathogenesis of RMSF relates to rickettsia-mediated vascular injury, but it is unclear in HME. METHODS To study histopathologic responses in the lymphatic system for correlates of immune injury, lymph nodes from patients with HM...

During the developmental process, there is an estimated 40 to 70% incidence of delay or failure for new drug entities due to poor biopharmaceutical properties such as poor solubility, poor permeability and poor chemical stability. Hot melt extrusion (HME) technology may provide the answer. HME, a solid-dispersion technology, has gained popularity in the pharmaceutical industry as a means of imp...

Multiple osteochondromas (MO), previously known as hereditary multiple exostoses (HME), is an autosomal dominant disease characterized by the formation of several benign cartilage-capped bone growth defined osteochondromas or exostoses. Various clinical classifications have been proposed but a consensus has not been reached. The aim of this study was to validate (using a machine learning approa...

BACKGROUND Magnetic resonance imaging (MRI) is useful in evaluating nontraumatic hip pain. It provides information about associated injuries like labral/chondral tears or ischiofemoral impingement (IFI). However, in hereditary multiple exostoses (HME) there has been no report about MRI findings in symptomatic children with hip involvement. METHODS Records of children with HME and hip osteocho...

Exostosis in external auditory canal is common among surfers. Common symptoms are decreased hearing or loss of hearing, ear infection, and/or plugging sensation. Repeated exposure to cold water is a key clinical history to suspect this condition. Based on symptoms and existence of infection, surgical removal of the exostosis is recommended.

In the presence of fluid helicity $\boldsymbol{v} \cdot \boldsymbol{\omega}$, magnetic field induces an electric current form $\boldsymbol{j} = C_{\rm HME} (\boldsymbol{v} \boldsymbol{\omega}) \boldsymbol{B}$. This is helical effect (HME). We show that for massless Dirac fermions with charge $e=1$, transport coefficient $C_{\rm HME}$ fixed by chiral anomaly $C=1/(2\pi^2)$ as C/2$ independently ...

BACKGROUND Hemimegalencephaly (HME) is a hamartomatous malformation of one cerebral hemisphere. As this is a disorder of cellular growth and lineage, we sought evidence of an early ontogenetic disturbance of microtubular assembly or function. MATERIAL AND METHODS Three male infants with HME had brain resections for refractory epilepsy. One died postoperatively at 2.5 months and an autopsy was...

To determine the incidence, clinical and laboratory characteristics, and utility of molecular diagnosis of human monocytotropic ehrlichiosis (HME) in the primary care setting, we conducted a prospective study in an outpatient primary care clinic in Cape Girardeau, Missouri. One hundred and two patients with a history of fever for 3 days (>37.7 degrees C), tick bite or exposure, and no other inf...