PURPOSE To describe the course and outcome of treatment of advanced Acanthamoeba sclerokeratitis with intravenous pentamidine. METHODS A case of advanced Acanthamoeba sclerokeratitis was resistant to conventional therapy and was treated with intravenous pentamidine. The eye was later removed due to incapacitating pain. RESULTS The eye showed Acanthamoeba organisms within the cornea and evid...

Moraxella keratitis has been commonly described as a disease of debilitated older patients, particularly malnourished chronic alcoholics. This communication reviews the features of corneal infection due to Moraxella nonliquifaciens occurring in both young and old patients in otherwise good general health. Chronic corneal epithelial disturbance was a common finding in the 8 patients reported, in...

We present the first two cases of Kingella kingae keratitis in adults. This species is a rare isolate from ophthalmic samples for which final identification was obtained with matrix-assisted laser desorption ionization-time of flight mass spectrometry. One of the patients recovered uneventfully with topical therapy. Results from the second patient cannot be confirmed as he was lost to follow-up.

A case of Scedosporium apiospermum keratitis is reported in a 65-year-old farmer referred for treatment of an extensive corneal ulcer in the left eye. Direct examination of scrapes revealed abundant filamentous septate hyphae; all cultures were consistently positive for the same fungus, identified later as Scedosporium apiospermum. The patient successfully responded to treatment with amphoteric...

A review of 87 cases of microbial keratitis in South Australia was made to determine the factors which influence the outcome of the disease. The preceding pathology and the extent of ulceration at presentation were found to be significant, while the presence of hypopyon was less important. Infection with Pseudomonas aeruginosa was most likely to result in a poor outcome. Most patients had a his...

PURPOSE To characterise the results of the largest patient series to date undergoing closed conjunctival delayed adjustable suture techniques. METHODS A multicentre retrospective review of 440 operations (patients aged 10-91 years) by five surgeons at four centres were evaluated for surgical outcomes associated with the delayed adjustable suture technique. RESULTS 26% (116 of 440) of all pa...

THE results of treating herpetic keratitis with the antiviral agent 5-iodo-2'deoxyuridine have proved, after initial enthusiasm, to be somewhat variable. In most instances the number of cases analysed has been small (Bennett, 1962; Corrigan, Gilkes, and Roberts, 1962; Davidson, 1962; Kaufman and Maloney, 1962; Luntz and MacCallum, 1963). More accurate conclusions can best be reached by a double...

Previous studies demonstrated that in the murine model of Onchocerca volvulus keratitis, neutrophils and eosinophils are recruited into the cornea in a biphasic manner in response to intrastromal injection. To determine if CD4(+) T cells regulate migration of neutrophils and eosinophils into the cornea, CD4(+) cells were depleted using monoclonal antibody GK1.5 before intrastromal injection of ...

Infections of the cornea can lead to corneal opacity and blindness if not identified quickly and managed appropriately. The terms infective keratitis, suppurative keratitis, and microbial keratitis are all used to describe suppurative infections of the cornea. These are characterised by the presence of white or yellowish infiltrates in the corneal stroma, with or without an overlaying corneal e...

Ophthalmic findings are reported in 31 eyes of 28 children with herpes simplex keratitis. Twenty two had dendritic ulcers, and nine had geographic ulcers or disciform stromal keratitis. After resolution of keratitis, 80% (19/22) of children with dendritic ulcers achieved corrected visual acuity of 6/9 or better, 50% (11/22) had induced astigmatism, 45% (9/22) had one to five recurrences. In the...