Homing endonucleases (HE) have emerged as precise tools for achieving gene targeting events. Redesigned HEs with tailored specificities can be used to cleave new sequences, thereby considerably expanding the number of targetable genes and loci. With HEs, as well as with other protein scaffolds, context dependence of DNA/protein interaction patterns remains one of the major limitations for ratio...

A popular approach to apprenticeship learning (AL) is to formulate it as an inverse reinforcement learning (IRL) problem. The MaxEnt-IRL algorithm successfully integrates the maximum entropy principle into IRL and unlike its predecessors, it resolves the ambiguity arising from the fact that a possibly large number of policies could match the expert’s behavior. In this paper, we study an AL sett...

BACKGROUND Hydroxyethyl starch (HES) solutions alter blood coagulation, mainly platelet function and fibrinogen polymerization. Haemostasis can also be impaired by dilutional-hyperchloraemic acidosis induced by the HES carrier solution. We hypothesized that a saline-based tetrastarch carrier solution impairs parameters of blood coagulation more than a balanced carrier solution. METHODS The st...

in this research three-dimensional free vibration analysis of functionally graded circular plate with various boundary conditions is achieved. a semi-analytical method, which makes use of the state space method and the one-dimensional differential quadrature method, is used to obtain the vibration frequencies and dynamic responses of circular plates. numerical results are given to demonstrate t...

BACKGROUND Electronic linkage to routine administrative datasets, such as the Hospital Episode Statistics (HES) in England, is increasingly used in medical research. Relatively little is known about the reliability of HES diagnostic information for epidemiological studies. In the United Kingdom (UK), general practitioners hold comprehensive records for individuals relating to their primary, sec...

This work proposes a semi-analytical method for simulation of the acoustic response of multipole eccentered sources in a fluid-filled borehole. Assuming a geometry that is invariant with respect to the azimuthal and vertical directions, the solution in frequency domain is expressed in terms of a Fourier series and a Fourier integral. The proposed semi-analytical method builds upon the idea of s...

The recent years have witnessed a surge of interest in graphbased semi-supervised learning methods. The common denominator of these methods is that the data are represented by the nodes of a graph, the edges of which encode the pairwise similarities of the data. Despite the theoretical and empirical success, these methods have one major bottleneck which is the high computational complexity (sin...

INTRODUCTION This prospective randomized clinical study investigated the efficacy and safety of 7.2% hypertonic saline hydroxyethyl starch 200/0.5 (7.2% NaCl/HES 200/0.5) in comparison with 15% mannitol in the treatment of increased intracranial pressure (ICP). METHODS Forty neurosurgical patients at risk of increased ICP were randomized to receive either 7.2% NaCl/HES 200/0.5 or 15% mannitol...