An N-heterocyclic carbene ligand precursor bearing a ?-extended phenanthridine (3,4-benzoquinoline) unit is presented. The proligand was isolated as the imidazolium salt of chloride (1•HCl), bromide (1•HBr), or hexafluorophosphate (1•HPF 6 ) counterions. These salts can be deprotonated and installed on silver centres using Ag 2 O both base source metal ion. resulting Ag(I) complex (1)AgCl used ...

Abstract Many cancers of neuroendocrine origin overexpress cholecystokinin-2 receptors (CCK-2R) including medullary thyroid cancer, small cell lung cancer and other carcinoids. Fluorine-18 labelled peptides targeting CCK-2R enable direct visualization quantification this receptor in vivo using positron emission tomography imaging. CP04 1 MG11 2 are two previously described truncated derived fro...

The unique properties and high synthetic flexibility of N-heterocyclic carbenes (NHCs) have made them highly attractive tools for the development new nanomaterials fundamental study their properties. In this review, we focus on case NHC-stabilized gold nanoparticles ([email protected]) with potential biological applications. AuNPs are ubiquitous in biomedicine, where they serve as versatile sca...

A series of eight Rhenium(I)-N-heterocyclic carbene (NHC) complexes of the general form [ReCl(CO)3(C^C)] (where C^C is a bis(NHC) bidentate ligand), [ReCl(CO)3(C^C)]2 (where C^C is a bis-bidentate tetra-NHC ligand) and [Re(CO)3(C^N^C)](+)[X](-) (where C^N^C is a bis(NHC)-amine ligand and the counter ion X is either the ReO4(-) or PF6(-)) have been synthesised using a Ag2O transmetallation proto...

N-Heterocyclic carbene-based silver complexes (Ag-NHCs) have been widely used as organometallic drug candidates in medicinal and pharmaceutical chemistry research due to their low toxicity. Due the success of Ag-NHCs biological applications, interest synthesis applications such compounds is increasing rapidly. Therefore, this study, ten Ag-NHC containing benzimidazol-2-ylidene ligand were synth...

1 mimicking axial chirality, in which a chiral carbon center induces a preferred conformation 2a by rotation around an N–Ar bond which is fixed by formation of a chelate structure with metal (Fig. 1). In order to expand the scope of our chiral mimetic concept, we planned to develop a novel N-heterocyclic carbene ligand 3. The substituent R on the sp N group in the carbene ligand 3 may be confor...

The mechanism of nickel(0)-catalyzed reductive coupling of aldehydes and alkynes has been studied. Extensive double-labeling crossover studies have been conducted. While previous studies illustrated that phosphine- and N-heterocyclic carbene-derived catalysts exhibited differing behavior, the origin of these effects has now been evaluated in detail. Many variables, including ligand class, steri...

We present the synthesis and structural characterization of novel ruthenium complexes containing C^C* cyclometalated N-heterocyclic carbene ligands, η(6)-arene (p-cymene) ligands and one bridging chlorine ion. Complexes of the general formula [Ru(p-cymene)(C^C*)Cl] were prepared via a one-pot synthesis using in situ transmetalation from the correspondent silver NHC complexes. These complexes re...