Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder associated with fragile X premutation carriers. Previous studies have shown that fragile X rCGG repeats are sufficient to cause neurodegeneration and that the rCGG-repeat-binding proteins Pur α and heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 could modulate rCGG-mediated neuronal toxicity. Mobile geneti...

The basic helix-loop-helix transcription factor hASH1, encoded by the ASCL1 gene, plays an important role in neurogenesis and tumor development. Recent findings indicate that local oxygen tension is a critical determinant for the progression of neuroblastomas. Here we investigated the molecular mechanisms underlying the oxygen-dependent expression of hASH1 in neuroblastoma cells. Exposure of hu...

AbstractWe propose a lightweight, single-image super-resolution mobile device network named XCAT, and introduce Heterogeneous Group Convolution Blocks with Cross Concatenations (HXBlock). The heterogeneous split of the input channels to group convolution blocks reduces number operations, cross concatenation allows for information flow between intermediate tensors cascaded HXBlocks. concatenatio...

This paper is devoted to the study of an optimal control problem for a generalized multi-group reaction–diffusion SIR epidemic model, with heterogeneous nonlinear incidence rates. The proposed model incorporates wide range spatiotemporal models. Primarily, ones used describe propagation zoonotic and sexually transmitted diseases, as well epidemics that propagate disparately within populations. ...

Queueing models have proven to be very useful in real-life applications enable the practitioners optimize limited resources conduct their businesses as well offer services efficiently. In general, we can group such into two sectors: manufacturing and service. These sectors cover everything deal with on a day-to-day basis. Queues which are offered blocks (or groups or batches) established litera...

in the present study, the synthesis of diethylene triamine supported on cellulose biopolymer as a biodegradable solid basic heterogeneous catalyst was suggested. then, the applicability of the synthesized catalyst cellulose bonded n-propyl diethylene triamine (cbpdeta) was tested for the synthesis of oxindole derivatives, an important class of potentially bioactive compounds. a various series o...