Hypertension induces vascular damage followed by organ damage, including heart failure in hypertensive disease (HHD) and nephrosclerosis (the resultant renal pathologic change from long-standing hypertension affecting supply), ultimately causing failure. Renin-angiotensin-aldosterone system (RAAS) inhibitors are well known as effective drugs for the treatment of anti-remodeling affected organs....

OBJECTIVES In searching for a noninvasive surrogate tissue mimicking the pro-oxidant/proinflammatory hypertensive heart disease (HHD) phenotype, we turned to peripheral blood mononuclear cells (PBMCs). We tested whether iterations in [Ca2+]i, [Zn2+]i, and oxidative stress in cardiomyocytes and PBMCs would complement each other, eliciting similar shifts in gene expression profiles in these tissu...

OBJECTIVE To investigate whether cardiac expression of the nuclear peroxisome proliferator-activated receptor alpha (PPARalpha) is altered in patients with hypertensive heart disease (HHD). METHODS We studied endomyocardial septal biopsies from 24 patients with essential hypertension divided into three groups: 6 without left ventricular hypertrophy (LVH) (HT group), 10 with LVH (LVH group), a...

BACKGROUND Myotonic dystrophy type 1 (DM1) is a multisystem disorder that demonstrates variable symptoms and rates of progression. Muscle weakness is considered one of the main problems with a clinical picture that is characterized by distal weakness of the limbs progressing to proximal weakness. The main objective of this study was to characterize the maximal strength of ankle eversion and dor...

Fig. 2 Conflict interest statement The authors declare that they have no conflict of interest to the publication of this article. Hepatic hydatid disease (HHD) is a unique parasitic disease that is endemic in many parts of the world [1]. Biliary rupture is one of the most common complications of HHD, which leads to small to large cysto-biliary communications (CBC) [1, 2]. CBC can cause cholangi...

Hailey-Hailey disease (HHD) is a rare autosomal dominant blistering skin disease first described in 1939. It is characterised by vesicular or crusted erosions on the neck and in intertriginous areas. Though it is known that the gene responsible for HHD is located on 3q21-q24, it is only recently found that the disease is a result of the mutations in the Ca2+ ATPase ATP2C1. A spectrum of mutatio...

Abstract Augmented Reality (AR) is a pillar of the transition to Industry 4.0 and smart manufacturing. It can facilitate training, maintenance, assembly, quality control, remote collaboration other tasks. AR has potential revolutionize way information accessed, used exchanged, extending user’s perception improving their performance. This work proposes Pervasive tool, created with partners from ...

BACKGROUND Leishmania is an intracellular parasite infecting humans and many wild and domestic animals. Recent studies have suggested an important role for cytotoxic T cells against Leishmania. Peptide-based vaccines targeting short sequences derived from known immunogenic proteins have been shown to elicit cellular immune responses against disparate pathogens. METHODS We predicted four HLA-A...

OBJECTIVE The use of hand held devices (HHD) such as mobile phones, game controls, tablets, portable media players and personal digital assistants have increased dramatically in past decade. While sending a text message or using the controls of the HHD the users need to use their thumb and other palm muscles extensively. The objective of this study was to describe the risk factors and clinical ...

To explore the direction of inter-scale transfer scalar variance between subgrid scale (SGS) and resolved fields, direct numerical simulation data obtained earlier from two complex-chemistry lean hydrogen–air flames are analysed by applying Helmholtz–Hodge decomposition (HHD) to simulated velocity fields. Computed results show backscatter (combustion progress variable $c$ ) variance, i.e. its S...