Many transport service providers operate on hub-and-spoke network structures. Major operators may have several dedicated hub facilities that are leased for a time horizon rather than being owned or constructed. For a given discrete planning horizon, service providers must decide on the location of the hub ports (i.e. terminals), the period when the lease contract starts, the period when the exi...

The most common malignant neoplasm of the head and neck region is laryngeal cancerwhich presents a significant international health problem. The present study aims to screenpotential proteins related to laryngeal cancer by network analysis to further understandingdisease pathogenesis and biomarker discovery. Differentially expressed proteins were extractedfrom literatures of laryngeal cancer th...

Genome-scale gene networks contain regulatory genes called hubs that have many interaction partners. These genes usually play an essential role in gene regulation and cellular processes. Despite recent advancements in high-throughput technology, inferring gene networks with hub genes from highdimensional data still remains a challenging problem. Novel statistical network inference methods are n...

The BusPlus project aims at improving the off-peak hours public transit service in Canberra, Australia. To address the difficulty of covering a large geographic area, BusPlus proposes a hub and shuttle model consisting of a combination of a few high-frequency bus routes between key hubs and a large number of shuttles that bring passengers from their origin to the closest hub and take them from ...

Digitalisation, accelerated by the pandemic, has brought opportunity for companies to expand their businesses beyond geographic location and considerably affected networks around world. Cloud services have a better acceptance nowadays, it is foreseen that this industry will grow exponentially in following years. With more distributed need support customers different locations, model of one-sing...

In the next few years, Brazil will host international events such as the 2014 FIFA World Cup and the 2016 Olympics Games. Given the worldwide appeal of these events, local authorities in Brazil expect the country will have around 1.6 million visitors arriving at its airports (1 million for the Olympics and 600 thousand for the World Cup). Therefore, these events will put to test the robustness ...

Metastatic melanoma is an aggressive skin cancer and is one of the global malignancies with high mortality and morbidity. It is essential to identify and verify diagnostic biomarkers of early metastatic melanoma. Previous studies have systematically assessed protein biomarkers and mRNA-based expression characteristics. However, molecular markers for the early diagnosis of metastatic melanoma ha...

Abstract For the energy hub system configuration, there are problems such as high operation and maintenance costs, poor safety, low efficiency of renewable utilization large pollution emissions. This paper proposes an configuration optimization method based on analytic hierarchy grey correlation analysis. First, configure model. Second, establish a model that includes installation efficiency, f...

Transport networks with hub structure organise the exchange of shipments between many sources and sinks. All sources and sinks are connected to a small number of hubs which serve as transhipment points, so that only few, strongly consolidated transport relations exist. While hubs and detours lead to additional costs, the savings from bundling shipments, i.e. economies of scale, usually outweigh...

In this work we address a capacitated hub problem arising from a Telecommunications application. In this problem we must choose the routes and the hubs to use in order to send a set of commodities from sources to destinations in a given capacitated network with a minimum cost. The capacities and costs of the arcs and hubs are given, and the graph connecting the hubs is not assumed to be complet...