Abstract Semitransparent organic solar cells (ST‐OSCs) can be made in different colors, allowing light to pass through, and yet absorb enough visible near‐infrared (NIR) generate electricity. However, it remains a challenge achieve high performing ST‐OSCs over the two competing indexes of power conversion efficiency (PCE) average transmittance (AVT). This work reports an effort develop record‐p...

Polymer micelles have been used widely in the delivery of various therapeutic drugs, which are also known as active pharmaceutical ingredients (APIs). Recent advances in drug discovery technology, including an accumulated database on therapeutic targets, combinational chemistry, and high-throughput screening (HTS), have further increased the number of candidate compounds and constructed a huge ...

As high-throughput sequencers become standard equipment outside of sequencing centers, there is an increasing need for efficient methods for pre-processing and primary analysis. While a vast literature proposes methods for HTS data analysis, we argue that significant improvements can still be gained by exploiting expensive pre-processing steps which can be amortized with savings from later stag...

The R package displayHTS implements recently developed methods and figures for displaying data and hit selection results in high-throughput screening (HTS) experiments. It generates not only certain useful distinctive graphics such as the plate-well series plot, plate image and dual-flashlight plot but also other commonly used figures such as volcano plot and plate correlation plot. These figur...

Fragment screening is the process of identifying relatively simple, often weakly potent, bioactivemolecules. It is gainingwide acceptance as a successful hit-finding technique both in its own right and as a method of finding hit molecules when traditional high-throughput screening (HTS) methods fail. Fragment hits are typically highly ‘ligand efficient’, i.e. possess a high binding affinity per...

Many of the structures in PubChem are annotated with activities determined in high-throughput screening (HTS) assays. Because of the nature of these assays, the activity data are typically strongly imbalanced, with a small number of active compounds contrasting with a very large number of inactive compounds. We have used several such imbalanced PubChem HTS assays to test and develop strategies ...

Over the past 15 years I have been involved in the development of several performance critical and highly available systems for telecommunications, process control, securities trading, and satellite management. All these systems have the goal of reaching at least 99.999% availability. In addition, they all have elements that require high performance. Some of these systems have pieces with hard ...