Transdermal drug delivery systems are polymeric patches containing dissolved or dispersed drugs that deliver therapeutic agents at a constant rate to the human body. Matrix type transdermal patches were prepared using alprazolam as a model drug and employing the combinations of chitosan-polyvinyl alcohol (CS-PVA) cross linked with Maleic anhydride. The transdermal patches were evaluated for the...

This paper investigates the automated detection of a patient’s breathing rate and heart rate from their skin conductivity as well as sleep stage scoring and breathing event detection from their EEG. The software developed for these tasks is tested on data sets obtained from the sleep disorders unit at the Adelaide Women’s and Children’s Hospital. The sleep scoring and breathing event detection ...

The present study was aimed to develop and evaluate nanoparticulate containing pioglitazone HCl as potential antidiabetic drug delivery system. The pioglitazone HCl -loaded chitosan nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions at various concentrations. The nanoparticles were characterized by zeta potential analyzer; particle size analyzer and Fourier t...

We present a simple numerical optimisation procedure to search for highly entangled states of 2, 3, 4 and 5 qubits. We develop a computationally tractable entanglement measure based on the negative partial transpose (NPT) criterion, which can be applied to quantum systems of an arbitrary number of qubits. The search algorithm attempts to optimise this entanglement cost function to find the maxi...

Hoon Kim, a,b John Ralph,* a,b Fachuang Lu, a,b Sally A. Ralph, c Alain-M. Boudett, d John J. MacKay, e Ronald R. Sederoff, f Takashi Ito, g Shingo Kawai, g Hideo Ohashi g and Takayoshi Higuchi h a US Dairy Forage Research Center, USDA Agricultural Research Service, Madison WI 53706. USA b Department of Forestry, University of Wisconsin, Madison, WI 53706-1598, USA c US Forest Product Laborator...

Prolonged release drug delivery system of stavudine was made by ionotropic gelation and polyelectrolyte complexation technique. Cross-linking reinforced chitosan-gellan complex beads were prepared by gelation of anionic gellan gum, the primary polymer, with oppositely charged counter ion to form beads which were further complexed with chitosan as a polyelectrolyte. The effect of this polymer on...

Let G be an infinite plane graph such that G is locally finite and every face of G is bounded by a cycle. Then G is said to be positively curved if, for every vertex x of G, 1− d(x)/2 + Σx∈F 1 |F | > 0, where the summation is taken over all facial cycles F containing x. Note that if G is positively curved then the maximum degree of G is at most 5. As a discrete analogue of a result in Riemannia...

Metformin hydrochloride is an orally administered first line drug which commonly used in the management of type-2 diabetes. To overcome the side effects of it due to high/repeated dose and patient inconvenience, the sustained release microparticles of metformin loaded RS100 were developed. The method used to prepared microparticles was novel oil in oil technique. Obtained microparticles were ch...

Ryuji Yamashita, Sagar Magia, Tsutomu Higuchi, Kazuhide Yoneya, Toshio Yamamura, Hiroyuki Mizukoshi, Shingo Zaitsu, Minoru Yamashita, Shunichi Toyama, Norihiro Kamae, Juan Lee, Shuo Chen, Jiawei Tao, William Mak, Xiaohua Zhang, Ying Yu, Yuko Utsunomiya, Yosuke Kato, Manabu Sakai, Masahide Matsumoto, Hardwell Chibvongodze, Naoki Ookuma, Hiroki Yabe, Subodh Taigor, Rangarao Samineni, Takuyo Kodam...

Real-time PCR continues to have a major impact across many disciplines of the biological sciences and this has been a driver to develop and improve existing instruments. From the fi rst two commercial platforms introduced in the mid 1990s, there is now a choice in excess of a dozen instruments, which continues to increase. Advances include faster thermocycling times, higher throughput, fl exibi...