BACKGROUND For devising potential clinical approaches for limb length discrepancies, we examined local administration of insulin-like growth factor 2 (IGF2). METHODS C57/BL/6 mice (∼ 8 weeks old) were used in this study, and the mice were separated into two groups: an IGF2-treated group and a placebo group. In the IGF2-treated group, IGF2 was locally administered into the distal epiphysis of ...

1 Arachidonic acid(AA) (25-200 mug/kg) produced a dose-related increase in perfusion pressure in dog isolated hind limbs perfused with either blood or a platelet-free perfusate. 2 Prostaglandin E2 produced vasodilation while prostaglandin F2 alpha produced no vascular change at these administered doses. 3 Phentolamine did not alter the arachidonic acid response, eliminating possible alpha-adren...

• a). By far the most common group is comprised of dairy cows, and occasionally beef cows, with hypocalcaemia. b). In beef heifers, most commonly Herefords, and occasionally in dairy heifers. Usually there is some evidence of at least minor dystocia. The soft tissues appear to have been stretched beyond their limits of immediate and adequate recovery. There is often, but not always, some loss o...

Digital dermatitis is a polybacterial disease process of dairy and beef cattle. Lesions are most commonly identified on the plantar aspect of the interdigital cleft of the hind limbs. Treponema spp are routinely present in large numbers of active lesions. Lesions are painful to the touch and can result in clinical lameness. The infectious nature generally results in endemic infection of cattle ...

Koch (1886) studied the effect of cholera vibrios on guinea-pigs by feeding the animals with big doses of the organisms and then paralysing the gut by intraperitoneal injection of 1 c.cm. of tincture of opium so as to delay evacuation. Out of 35 animals, 30 died showing weakness of the hind limbs and collapse. The small intestine was deeply injected and filled with a;flocculent colourless fluid...

this case report illustrates the presence of diffuse idiopathic skeletal hyperostosis (dish) in a fighting bulldog. the dog was referred to the veterinary teaching hospital, university of agriculture faisalabad pakistan, with the presenting complaint of slowly progressing staggering gait, inability to stand on hind limbs and muscle stiffness in lumbo-sacral region. hematological, serobiochemica...

the dysesthesia and paresthesia that occurs in laboratory rats after spinal cord injury (sci) results in autophagia. this self-destructive behavior interferes with functional assessments in designed studies and jeopardizes the health of the injured rat. in this study, we evaluated role of saturated picric acid in the prevention of autophagia and self-mutilation. all rats were anesthetized with ...

In family Lemuridae, anatomical variations exist. Considering its conservation status (near threatened) and presence of similarities between strepsirrhines and primitive animals, it was thought to be beneficial to describe the gross osteology and radiographic anatomy of the pelvis and hind limb of ring-tailed lemurs (Lemur catta) as a reference for clinical use and species identification. Radio...

The aetiology of complex regional pain syndrome (CRPS), a highly painful, usually post-traumatic condition affecting the limbs, is unknown, but recent results have suggested an autoimmune contribution. To confirm a role for pathogenic autoantibodies, we established a passive-transfer trauma model. Prior to undergoing incision of hind limb plantar skin and muscle, mice were injected either with ...