Cisplatin had shown anti-leishmanial effect both in vitro and in vivo against murine visceral leishmaniasis. The present study was designed to evaluate the effect of cisplatin on gonads of Leishmania donovani infected BALB/c mice. In drug treated animals, mild reduced spermatogenesis was observed but when antioxidants were supplemented along with cisplatin, the morphological characteristics of ...

Periapical tissue from 58 cases requiring periapical surgery was examined histologically and cultured for the presence of microbes. Twenty-nine had a possible oral cavity communication and 29 did not. Approximately one-half of each biopsy was submitted for culture while the other portion was examined histologically. Cultures were positive for the presence of bacteria in 51 of 58 cases while bac...

Objective(s): Newer organo-metallic, specifically gold (III) complexes with multiple ligands are currently being formulated with primary focus of having increased anti-cancerous properties and decreased cytotoxicity. In this study, histological toxicity profile of a newly formulated anti-cancerous gold (III) compound [trans-(±)-1,2-(DACH)2Au]Cl3 Bis(trans-1,2-Diaminocyclohexane) was investigate...

BACKGROUND Interstitial pneumonias (IP) cover a broad spectrum of diseases. Open lung biopsies reveal histological patterns and suggest possible diagnoses. Complete clinical records are necessary for final diagnoses. Especially idiopathic interstitial pneumonias (IIP) according to the ATS/ERS classification can only be diagnosed under these predictions. The aim of this study was to compare the ...

introduction paragangliomas are mostly localized in the adrenal medulla and they are usually pheochromocytomas, derived from the neural crest, but otherwise mesenteric paragangliomas are extremely rare tumors. case presentation in this article we represent a 59-year-old female with an abdominal mass and pain due to mesenteric paraganglioma. conclusions paragangliomas can occur as mesenteric tum...

malignant peripheral nerve-sheath tumor (mpnst) is a high-grade malignant tumor of ecto-mesenchymal origin comprising approximately 10% of soft-tissue sarcomas. they tend to occur associated with neurofibromatosis or sporadically. here we report a mpnst at an extremely rare location and behavior causing disappearance of the entire kidney. patient evaluation included clinical, biochemical and ra...

A case of bilateral primary choroidal melanoma is described in a 51-year-old white male. Histological confirmation followed enucleation of the left eye and local excision in the right. A careful systemic evaluation failed to demonstrate any other primary or secondary melanomata. This case is the first bilateral primary choroidal melanoma reported in the United Kingdom and the first to be descri...

Musculoskeletal disorders may be the primary manifestations of scleroderma. The case is reported of a patient admitted for an evaluation of severe knee flexion contractures who was diagnosed as having scleroderma but lacked the typical presenting features of the disease. Radiographic, serological, and histological support for this diagnosis are presented. Scleroderma should be considered in the...