A poorer response to hepatitis B vaccination, in coeliac subjects, compared to healthy subjects, has been largely debated. Almost all authors postulated that human leu-kocyte antigen (HLA) genotype DQ2, found in 90-95% of coeliac patients, could represent the main cause in determining the impaired antibody response to recombinant HBV vaccine (1), as well as observed also in healthy not responde...

Two hundred and eighty nine unrelated Marathas residing in Mumbai, Maharastra, (Western India) were studied for HLA A, B, C and DR locus antigen profiles. The HLA antigen maximum likelihood gene frequencies of HLA A1, A2, A9 (24), A11, A19 (33), B5, B7, B35, B40 (61), Cw3, Cw6, DR2, DR5, DR7, DQ1 and DQ2 were increased while that of HLA A3, A10 (26), A36, B8, B13, B16 (38), B18, B21, B22 (55), ...

Coeliac disease has a strong genetic component, higher than for many other common complex diseases. Possession of the HLA-DQ2 variant is required for presentation of disease causing dietary antigens to T cells, although this is also common in the healthy population. Non-HLA genetic factors account for the majority of heritable risk. Linkage studies have identified promising regions on chromosom...

A 62-year-old woman complaining of severe malabsorption was diagnosed with celiac disease based on the findings of flat, small intestinal mucosa and HLA-DQ2 positivity, although celiac serology was negative. This diagnosis was questioned due to the lack of clinical and histological improvement after a long period of strict gluten-free diet. The detection of enterocyte autoantibodies guided to t...

Microscopic colitis (MC) is an inflammatory condition of the large bowel that is associated with chronic, nonbloody diarrhea. Colonoscopy usually demonstrates normal mucosa, while tissue biopsy reveals intraepithelial lymphocytes or a subepithelial collagen band. Although no specific antibody has been discovered, MC is associated with several autoimmune disorders such as celiac disease, Hashimo...

Celiac disease (CD) is an autoimmune disorder that occurs in genetically susceptible individuals of all ages and is triggered by immune response to gluten and related proteins. The disease is characterized by the presence of HLA-DQ2 and/or -DQ8 haplotypes, diverse clinical manifestations, gluten-sensitive enteropathy, and production of several autoantibodies of which endomysial, tissue transglu...

The prevalence of coeliac disease (CD) in systemic lupus erythematosus (SLE) is unclear since evidence of this co -association is scarce. Furthermore, CD -specific antibodies have been described in patients with SLE without biopsy -confirmed CD. Here we describe the diagnostic challenges of CD in a patient suffering from SLE and secondary antiphospholipid syndrome, with transient positive serum...

Objectives Coeliac disease (CD) is a complex autoimmune disorder with known genetic risk factors. Approximately 1% of individuals of European ancestry have CD, but the prevalence among different ethnicities living in Canada remains unknown. The objective of the present study was to determine the prevalence of positive CD serology in a population of Canadian adults living in Toronto, and to dete...

Celiac disease (celiac sprue or gluten-sensitive enteropathy) is an inflammatory autoimmune disease of the small intestine that occurs in genetically susceptible (HLA DQ2 or DQ8 ) individuals upon exposure to dietary gluten.1 Gluten (gliadin and glutenin, found in wheat, rye, and barley) comprises a family of prolineand glutamine-rich proteins. Celiac disease is common, affecting 0.5 to 1% of t...