purpose: true neoplasm (adenocarcinoma) of retinal pigment epithelium (rpe) is very rare since it can be misdiagnosed as intraocular malignant melanoma it is of importance to know the clinical and pathologic aspects of this neoplasm. here, we report a case of adenocarcinoma of rpe. methods: case report. results: a 60-year-old man with progressive loss of the vision of the right eye was enucleat...

1Departments of Medicine (Gastroenterology) and 2Pathology, University of British Columbia, Vancouver, British Columbia Correspondence: Dr Hugh J Freeman, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, British Columbia V6T 1W5. Telephone 604-822-7216, e-mail [email protected] Received for publication January 24, 2014. Accepted February 7, 2014 CASE PRESENTATION A 70-year-...

Primary malignant melanoma of sinonasal tract is a rare but severe form of melanoma. We retrospectively analyzed 17 cases and focused on the histologic presentation and the expression of c-Kit, epidermal growth factor receptor (EGFR), cyclin D1/Bcl-1, PS100, and HMB45 and searched for BRAF, NRAS, and KIT mutations that are known to be associated with melanoma subtypes, together with amplificati...

emergency room with hematochezia. Apart from a low hemoglobin level (8.9 g/dL), laboratory findings were unremarkable. On colonoscopy, a large mass with a dark-stained surface was observed extending from the anus up to 3 cm above the anal verge (●" Fig. 1). When the mass was examined after retroflexion, it was noted that the ulcerating mass itself was surrounded by black pigmented mucosa (●" Fi...

BACKGROUND Clear cell sarcoma (CCS), also known as malignant melanoma of soft parts, is a rare type of soft tissue sarcoma which exhibits morphological, immunohistochemical and ultrastructural similarity with malignant melanoma. It is rarely localized in the intestine and the natural history of this tumor is not yet clear. CASE REPORT A 49-year-old woman presented with diffuse abdominal colic...

BACKGROUND Combination therapy with BRAF V600E inhibitor dabrafenib and MEK inhibitor trametinib significantly improves progression-free survival of patients with BRAF V600-positive metastatic melanoma, but their use can be associated with life-threatening toxicities. We report the case of a patient receiving dabrafenib and trametinib for metastatic melanoma who developed intracranial hemorrhag...

UNLABELLED Pheochromocytomas (PCC) and paraganglioma (PGL) are rare neuroendocrine tumors arising from chromaffin cells of the neural crest. Mutations in the RET-proto-oncogene are associated with sporadic pheochromocytoma, familial or sporadic medullary thyroid carcinoma (MTC) and multiple endocrine neoplasia type 2. In the past, only few cases of pigmented PCCs, PGLs, and one case of pigmente...

Primary cutaneous neuroendocrine tumors (NET) except for Merkel cell carcinoma have rarely been reported. Herein reported is a very unique case of primary cutaneous NET with immunohistochemical markers of myoepitheliomas. A 47-year-old woman presented a tumor measuring 0.8x0.9x0.6 cm of the face. The tumor was excised completely with wide margins. Morphologically, the tumor was located in the d...

Meningiomas arise from the meninges of the brain or spinal cord. They are the most common tumors of the central nervous system (CNS). Cutaneous meningiomas are rare tumors. Most of them occur in the head and neck. Several theories exist to explain their histogenesis. Lopez et al. have postulated classification of cutaneous meningiomas based on simple clinical and pathological features. Three di...

Purpose: To develop a genome-based classification scheme for clear-cell sarcoma (CCS), also known as melanoma of soft parts (MSP), which would have implications for diagnosis and treatment. This tumor displays characteristic features of soft tissue sarcoma (STS), including deep soft tissue primary location and a characteristic translocation, t(12; 22)(q13;q12), involving EWS and ATF1 genes. CCS...