نتایج جستجو برای: hmsh2
تعداد نتایج: 448 فیلتر نتایج به سال:
EDITOR—Hereditary non-polyposis colorectal cancer (HNPCC) syndrome is a common autosomal dominant predisposition to colorectal cancer. Clinical diagnostic features of sporadic and HNPCC associated colorectal cancer do not diVer significantly and until recently the identification of HNPCC patients was based mainly on their family history. Because of the importance for relatives of HNPCC patients...
EDITOR—Hereditary non-polyposis colorectal cancer (HNPCC) is a heterogeneous autosomal dominant disease with incomplete penetrance. The frequency is estimated at 1:200/1:1000. HNPCC results from constitutional mutation in one of the five human mismatch repair genes (MMR) that have so far been implicated: hMSH2, hMLH1, hPMS1, hPMS2, and hMSH6. 2 hMSH2 and hMLH1 account for the majority of mutati...
EDITOR—Hereditary non-polyposis colorectal cancer (HNPCC) is a heterogeneous autosomal dominant disease with incomplete penetrance. The frequency is estimated at 1:200/1:1000. HNPCC results from constitutional mutation in one of the five human mismatch repair genes (MMR) that have so far been implicated: hMSH2, hMLH1, hPMS1, hPMS2, and hMSH6. 2 hMSH2 and hMLH1 account for the majority of mutati...
EDITOR—Hereditary non-polyposis colorectal cancer (HNPCC) is a heterogeneous autosomal dominant disease with incomplete penetrance. The frequency is estimated at 1:200/1:1000. HNPCC results from constitutional mutation in one of the five human mismatch repair genes (MMR) that have so far been implicated: hMSH2, hMLH1, hPMS1, hPMS2, and hMSH6. 2 hMSH2 and hMLH1 account for the majority of mutati...
It has recently been shown that hereditary nonpolyposis colorectal cancer (HNPCC) is caused by hereditable defects in DNA mismatch repair genes. However, the fraction of HNPCC due to defects in any one repair gene and the nature of these mutations are not known. We analyzed 29 HNPCC kindreds for mutations in the prototype DNA mismatch repair gene li.MSIIl by a combination of linkage analysis, p...
The “mutator hypothesis” asserts that gene alterations that increase the rate of spontaneous mutation (mutators) underlie tumorigenesis (1, 2). However, the lack of a clear initial selection for the mutation of a mutator gene has been a contentious issue in cancer biology (3). Several recent functional studies have demonstrated a direct link between the human MMR proteins and signaling to the D...
Hereditary cancers are thought to account for around 5% of cancers, particularly breast/ovarian and colorectal cancers. In India there is a paucity of data on hereditary cancers and the mutations in some of the common genes linked to hereditary cancers, such as BRCA1, BRCA2, hMSH2 and hMLH1. The country's first comprehensive hereditary cancer clinic was established in February 2002. The article...
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