Ethanol cannot be excreted and must metabolized in the liver. Alcoholic liver disease is a blanket term for conditions related specifically to alcohol use. The study aimed evaluate metabolic, biochemical histological effects of oral supplementation with ?-carotene on C57BL/6 mice exposed ethanol consumption. Thirty male (Mus musculus) were divided into six experimental groups: Control (C), Low-...

BACKGROUND The effect of lixisenatide-a prandial once-daily glucagon-like peptide-1 receptor agonist-on glycaemic control in patients with inadequately controlled type 2 diabetes mellitus (T2DM), stratified by baseline β-cell function, was assessed. METHODS The 24-week GetGoal-M, -P and -S trials evaluated the efficacy and safety of lixisenatide in combination with oral antidiabetic agents. T...

BACKGROUND We investigated the relationships of adiponectin/leptin (A/L) ratio with cardiovascular risk factors, insulin resistance index, and metabolic syndrome (MS) in apparently healthy Korean male adults. METHODS Sixty-eight male subjects were enrolled among the participants of an annual health check-up program (mean age, 55.1 years). Percent body fat (%) was measured using a bioelectric ...

AIM To carry out randomized trial for evaluating effects of autologous bone marrow derived stem cell therapy (ABMSCT) through different routes. METHODS Bone marrow aspirate was taken from the iliac crest of patients. Bone marrow mononuclear cells were separated and purified using centrifugation. These cells were then infused in a total of 21 patients comprising three groups of 7 patients each...

BACKGROUND Polycystic ovary syndrome (PCOS) is associated with insulin resistance (IR) and compensatory hyperinsulinemia. IR is recognized as a major risk factor for the development of type 2 diabetes mellitus. However, few studies have investigated IR in women with PCOS and normal glucose tolerance. The objective of this study was to evaluate IR and β-cell function in women with PCOS and norma...

Objective: To observe the changes in insulin resistance patients with gestational diabetes mellitus (GDM) based on detection of serum microRNA-372-3p and glucose transporter protein 4 (GLUT4) levels. Methods: We conducted a retrospective cohort study 42 who were diagnosed GDM hospitalized our hospital during period from January 2017 to December 2021 another had normal pregnancy same by collecti...

Background: Diabetes is one of the most prevalent endocrine disorders in humans, and its first-line medication metformin. Peroxisome proliferator-activated receptor gamma (PPAR–γ) agonists are adjuncts to Bavachinin a PPAR pan-agonist with fewer side effects than metformin" into PPAR–γ agonists. In this study, synergistic metformin were investigated on type II diabetic rats. Methods: After four...

The in situ measured average outdoor absorbed dose rate in air was found to vary from 108.4 to 1596.4 nGy h at Homa Mountain area in southwestern Kenya. Rock and soil samples collected gave average values of the radioactivity concentrations of K, Ra and Th of 915.6, 195.3 and 409.5 Bq kg, respectively. The range of the annual effective dose for a person living in Homa Mountain area calculated v...

OBJECTIVE The study was to determine whether being the macrosomic offspring of a mother without detected glucose intolerance during pregnancy has an impact on lipid profile, glucose homeostasis, and blood pressure during childhood. RESEARCH DESIGN AND METHODS Plasma total, HDL, and LDL cholesterol; triglycerides; apolipoprotein (Apo) A-1, -B, and -E; lipoprotein (a); fasting glucose and insul...