This paper describes and discusses the impacts of the passage of cold fronts on the vertical structure of the Carlos Botelho (Lobo-Broa) Reservoir as demonstrated by changes in physical, chemical, and biological variables. The data were obtained with a continuous system measuring 9 variables in vertical profiles in the deepest point of the reservoir (12 m) coupled with climatological informatio...

Two new species of Dolichothele Mello-Leitão, 1923 are described from Brazil and Bolivia, D. mottaisp. n. from Distrito Federal and the state of Goiás, Brazil, and D. camargorumsp. n. from the state of Rondônia, Brazil, and the La Paz region, Bolivia. Males of the two new species resemble Dolichothele bolivianum (Vol, 2001) in having a small subapical keel on the distal embolus and females in p...

Concern over polycyclic aromatic hydrocarbons (PAHs) in foodstuffs was started during the 1960s and 1970s, where two classes of food toxicants producing tumours have been focused i.e. polycyclic aromatic hydrocarbons (PAHs) and N-nitroso compounds (Jägerstad and Skog, 2005). PAHs are referring to a series of organic compound containing two or more fused aromatic rings (Danyi et al., 2009; El-Ba...

Building on the discovery that MyoD expression reprograms fibroblasts into muscle, three papers (Vierbuchen et al., 2010; Ieda et al., 2010; Szabo et al., 2010) recently reported the reprogramming of fibroblasts into neurons, cardiomyocytes, and blood cell progenitors without first passing the cells through a pluripotent state. Here we discuss the advantages and challenges of harnessing this di...

Stroke is one of the major causes of death and disability in developed countries. The central nervous system (CNS) is known for its limited reparative capacity, but several studies demonstrated that the CNS has some reparative potential and cerebral ischemia is followed by activation of endogenous neurogenesis (Nakatomi et al., 2002; Taguchi et al., 2004). It is well-known that new neurons are ...

New assays are revealing that the diploid human genome contains extensive amounts of structural variation. Genome-wide approaches described in three papers in this issue (Beck et al., 2010; Huang et al., 2010; Iskow et al., 2010) paint a dynamic portrait of our genome, revealing a prominent role for repetitive sequences in shaping its structural variation.

Cancer immunotherapies have shown considerable promise in pre-clinical studies, but the potency of these interventions has often proved disappointing in vivo. This is in part due to tumor infiltration by myeloid cells, which are usually associated with less favorable clinical outcomes. In the past decade, several distinct subsets of tumor-infiltrating myeloid cells have been described (Movahedi...

et al. 1993, Wassenaar and Hobson 1998, Miller et al. 2010, 2012, Flockhart et al. 2013), while those that overwinter along the coast of California emerged from natal habitats west of the Rocky Mountains (Urquhart and Urquhart 1977, Nagano et al. 1993, Wenner and Harris 1993, Dingle et al. 2005, Stevens and Frey 2010). However, recent studies suggest that there may be significant interchange be...

Recently, Schmidt and colleagues reported that immunoglobulin Kappa C (IGKC) predicts a favourable response to chemotherapy and better metastasis-free survival in breast cancer patients (Schmidt et al., 2012). The authors validated the prognostic and predictive role of IGKC in 1,810 breast cancer, 1,056 non-small cell lung cancer and 513 colorectal cancer patient samples. The identification of ...

Received 6 January 2011 Accepted 14 January 2011 One of the most significant consequences of climate warming is the likely change in streamflow as a result of warming air temperatures. Hydrologists have responded to the challenge of understanding these effects. Many recent studies quantify historical trends in streamflow and usually attribute these trends to climate warming, via altered evapotr...