Microtubule-severing enzymes are critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles, and cilia where tubulin detyrosination, acetylation, and glutamylation are abundant. These modifications exhibit stereotyped patterns suggesting spatial and temporal control of microtubule functions. Using human-engineered and differentially modified microtubules we fin...

Positioning of the mitotic spindle is crucial for proper cell division. In the budding yeast Saccharomyces cerevisiae, two mechanisms contribute to spindle positioning. In the Kar9 pathway, astral microtubules emanating from the daughter-bound spindle pole body interact via the linker protein Kar9 with the myosin Myo2, which moves the microtubule along the actin cables towards the neck. In the ...

Disinfection of drinking water typically produces a mixture of mono-, di-, and tri-halogenated acetic acids (HAAs). In this study, we investigated the toxicokinetics of HAA mixtures in naive and glutathione transferase zeta 1 (GSTzeta)-depleted male F344 rats administered orally or iv to Mixture-1 (monobromo [MBAA]- dichloro- [DCAA], chlorodibromo- [CDBAA], tribromo- [TBAA] acetic acids) or Mix...

The interaction of galaxies not only occurs in galactic scales, but also may be linked to the binary cores in active galactic galaxies. The presence of a binary in the center of galaxies was suggested by Begelman, Blandford and Rees (1980). Gaskell (1983) suggests that supermassive binaries may account for the observed structure of emission line profiles such as double peaks displaced by a sign...

It is an emerging concern that a series of disinfection byproducts (DBPs) produced in wastewater effluent have adversely impacted the downstream aquatic system and drinking water resources. The occurrence, fate, and transport of DBPs on receiving waterbodies, however, are currently not well-documented. To fill the knowledge gap, this study simulated the effects of volatilization and adsorption ...

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Blumberg's discovery of the Australia antigen or hepatitis-associated antigen (HAA) and the subse quent demonstration of its relationship to serum hepatitis was a major contribution in the search for a method to eliminate carriers of serum hepatitis as potential blood donors (1,2). In a recent study of patients who had received blood transfusions that were serologically positive for HAA, three-...

BACKGROUND Trihalomethanes (THMs) occurring in public drinking water sources have been investigated in several epidemiological studies of fetal death and results support a modest association. Other classes of disinfection by-products found in drinking water have not been investigated. AIMS To investigate the effects of haloacetic acid (HAA) compounds in drinking water on stillbirth risk. ME...

We analyzed the outcomes of 44 children with hepatitis associated aplastic anemia (HAA) who received immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA). Fourteen (31.8%) patients achieved complete response and 17 (38.6%) achieved partial response, for an overall response rate of 70.4% after 6 months. Seven non-responders received bone marrow transplantation...