OBJECTIVE This study aimed to evaluate the role of high risk HPV DNA testing in identifying Chinese younger women with abnormal cytology at risk of harboring cervical intraepithelial neoplasia at grade 2 (CIN2) or worse so as to popularize an effective triage strategy for younger women. METHODS A total of 246 younger women aged 25 - 36 years old with abnormal cytology were recruited in our st...

BACKGROUND In delayed HPV triage women with atypical squamous cells of uncertain significance (ASC-US) cytology are retested after 6-12 months in order to decide whether they should be referred for colposcopy, further follow-up cytology or routine screening in three years. Triage using a specific HPV E6/E7 mRNA test may reduce referrals for colposcopy of women with ASC-US cytology compared to H...

OBJECTIVE To improve the diagnosis of cervical neoplasia by early detection of human papillomavirus (HPV) in uterine cervix, by adding molecular testing of HPV using hybrid capture 2 (HC2) and polymerase chain reaction (PCR) tests to Papanicolaou (Pap) test. METHODS One hundred women were enrolled in this study. The mean age (mean +/- SD) was 41.97 +/- 8.76 years and the range was 27-65 years...

OBJECTIVE Little is known about the information providers share with patients when ordering a co-test, or combined human papillomavirus (HPV) and Papanicolaou (Pap) test, for cervical cancer screening. We assessed provider perceptions of such communication practices with female patients aged 30-60 years. METHODS We analyzed data from 98 providers in 15 Federally Qualified Health Center clinic...

BACKGROUND Detection of cervical high grade lesions in patients with atypical squamous cells of undetermined significance (ASCUS) is still a challenge. Our study tested the efficacy of the paired boxed gene 1 (PAX1) methylation analysis by methylation-sensitive high-resolution melting (MS-HRM) in the detection of high grade lesions in ASCUS and compared performance with the hybrid capture 2 (HC...

BACKGROUND The Abbott RealTime High Risk HPV test (RealTime) is a novel assay designed to detect 14 high-risk human papillomavirus genotypes (hr-HPV) and concurrently distinguish HPV-16 and HPV-18 from other hr-HPV within a single test. OBJECTIVE To evaluate analytical specificity and clinical sensitivity for cervical carcinoma and cervical intraepithelial neoplasia grade 3 (CIN3) of the Real...

The Validation of Human Papillomavirus (HPV) Genotyping Tests (VALGENT) studies offer an opportunity to clinically validate HPV assays for use in primary screening for cervical cancer and also provide a framework for the comparison of analytical and type-specific performance. Through VALGENT, we assessed the performance of the cartridge-based Xpert HPV assay (Xpert HPV), which detects 14 high-r...

abstract background and aims: the human papilloma virus was introduced as the major etiological agent in outbreak of cervical cancer in 1970. since it is impossible to recognize these viruses and these types using the serological tests and cell culture, molecular methods such as pcr are of great importance. therefore, in this study, our goal was to use a multiple specific pcr assay on l1 and e6...

Cervical cancer remains the fourth most common among women worldwide, accounting for more than 500 000 new cases annually. can be effectively prevented through screening, which allows detection and treatment of precursor lesions, thereby preventing their progression to cancer. Following introduction Papanicolaou smear cytology-based screening (and later liquid-based cytology [LBC]), cervical in...

Infection with the human papillomavirus (HPV) has been identified as a major risk factor for oropharyngeal cancer (OPC). HPV-related OPCs have shown to be more radiosensitive and reduced related death. Hence, histological determination of HPV status patients depicts an essential diagnostic factor. We investigated ability deep learning models imaging based detection. To overcome problem small me...