Heat stress (HS) dramatically disrupts the events in energy and nutrient metabolism, many of which requires zinc (Zn) as a cofactor. In this study, metabolic effects of HS and Zn supplementation were evaluated by examining growth performance, blood chemistry, and metabolomes of crossbred gilts fed with ZnNeg (no Zn supplementation), ZnIO (120 ppm ZnSO4), or ZnAA (60 ppm ZnSO4 + 60 ppm zinc amin...

HS (heparan sulfate) is essential for normal embryonic development. This requirement is due to the obligatory role for HS in the signalling pathways of many growth factors and morphogens that bind to sulfated domains in the HS polymer chain. The sulfation patterning of HS is determined by a complex interplay of Golgi-located N- and O-sulfotransferases which sulfate the heparan precursor and cel...

The heat shock (HS) response is essential for survival of all organisms. Although the machinery of the HS response has been extensively investigated at the cellular level, it is poorly understood at the level of the organism. Here, we show the crucial role of the mushroom body (MB) in the HS response in Drosophila. Null mutants of the mitochondrial phosphatase Drosophila PGAM5 (dPGAM5) exhibite...

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body and presenting with painful nodules, abscesses, sinus tracts, and scarring. HS is a multifactorial disease in which genetic and environmental factors play a key role. The primary defect in HS pathophysiology involves follicular occlusion of the folliculopilosebaceous un...

In order to determine whether the relative rigidity of the hereditary spherocytosis (HS) red cell is due to membrane rididity or merely to an altered surface/volume ratio, we investigated the deformability of resealed red cell membranes from patients with HS. Whereas the osmotic fragility of intact red cells of HS patients showed the expected increase, the osmotic fragility of resealed HS membr...

Meet the abstract. This is the abstract. 1. A SEQUENCE OF STANDARD NORMALS Suppose x and y are two standard normal random variables , with correlation ρ. The bivariate normal density isφρ(•,•) and the univariate normal density isφ(•). The function s(•) is the standardized Hermite-Chebyshev polynomial of order s, with s = 0,1, · · ·. Mehler’s formula tells us that for all s ∫ +∞ −∞ φρ(x, y)hs(y)...

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterized by recurring abscesses, nodules, and fistulas predominantly in the groin and axillae. The association between HS and Crohn's disease (CD) has been well documented. Tumor necrosis factor (TNF) inhibitors have shown to be effective in treating both HS and CD. We report 2 patients who developed HS while on TNF inhi...

Abstract Background The clinical performance of the novel high-sensitivity cardiac troponin I EXL (hs-cTnI-EXL) assay is unknown so far. Purpose We aimed to validate hs-cTnI-EXL and derive an hs-cTnI-EXL-specific 0/1h-algorithm for early diagnosis myocardial infarction (MI). Methods This multicenter study included patients presenting emergency department with symptoms suggestive infarction. Cen...

BMI: body mass index HS: hidradenitis suppurativa HOMA-IR: homeostasis model of insulin resistance IR: insulin resistance BACKGROUND Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin condition characterized by recurrent, painful abscesses, nodules, and draining sinus tracts. The primary sites of involvement are the intertriginous skin areas of the axilla, groin, perianal...

RATIONALE Hypernatremia is a rare but fatal complication of hypertonic saline (HS) irrigation in hepatic hydatid disease. It needs careful monitoring and treatment. PATIENT CONCERNS A 28-year-old woman with hepatic hydatid cysts who received operation treatment developed electrolyte disturbances. We also conducted a retrospective study about influence of HS application on electrolytes in pati...