The advent of high-throughput sequencing (HTS) technologies is enabling sequencing of human genomes at a significantly lower cost. The availability of these genomes is hoped to enable novel medical diagnostics and treatment, specific to the individual, thus launching the era of personalized medicine. The data currently generated by HTS machines require extensive computational analysis in order ...

With the continuing improvement of properties of High Tc Superconductors (HTS), their application to accelerator technology is becoming increasingly attractive. While the medium to long-term goal for their use in this field will be for high field magnets, the materials now available enable a number of specific applications which benefit from their characteristics and make them a valid alternati...

With the continued expansion of corporate information systems and the increasing use of networks, information security management (ISM) has become more important than ever. However, few empirical studies have examined the effects of firms’ internal and external factors on their ISM processes. This study investigates the role of Need Pull and Technology Push on the ISM process, and examines the ...

OBJECTIVES The interferon (IFN) signature (IS) in patients with systemic lupus erythematosus (SLE) includes over 100 genes induced by type I IFN pathway activation. We developed a method to quantify the IS using three genes-the IS metric (ISM)-and characterised the clinical characteristics of patients with SLE with different ISM status from multiple clinical trials. METHODS Blood microarray e...

We read with great interest the study by Chen and colleagues highlighting interest in hydroxyethyl starch (HES) 130/0.4 in treatment after hemorrhagic shock to ameliorate oxidative stress and the inflammatory response in a rat model. Compared with HES 200/0.5 and succinylated gelatin, the authors showed that infusions of HES 130/0.4 significantly reduced malondialdehyde levels and myeloperoxida...

A method of moment with an enhanced model to design high-temperature superconductor (HTS) RF surface coils for magnetic resonant image (MRI) is presented. The resonant frequency and quality factor ( ) of HTS RF spiral coils are simulated using this method. The agreements of resonant frequencies and s between the simulation and measurement are excellent with differences less than 1% and 3%, resp...

BACKGROUND L-Threonine is an important amino acid for animal feed. Though the industrial fermentation technology of threonine achieved a very high level, there is still significant room to further improve the industrial strains. The biosensor-based high-throughput screening (HTS) technology has demonstrated its powerful applications. Unfortunately, for most of valuable fine chemicals such as th...

The present paper describes an HMM-based speech synthesis system developed by the Nitech-NAIST group for the Blizzard Challenge 2006 (Nitech-NAIST-HTS 2006). To achieve improvements over the 2005 system (Nitech-HTS 2005), new features such as MGC-LSP, MLLT, and full covariance GV pdf are investigated. Subjective listening test results show that combining mel-cepstral coefficients, MLLT and full...