BACKGROUND AND PURPOSE Acute stroke clinical trials are conducted primarily at academic medical centers. As a result, patients living in rural areas are excluded from participation, results may not be generalizable to nonacademic settings, and studies may be slow to recruit subjects. Telemedicine can provide rural patients with emergency neurovascular consultation. We sought to determine whethe...

The deregulation of aviation markets led to restructuring of airline networks. Hub-andspoke networks became the dominant network in countries (regions) where aviation markets were deregulated. These developments were primarily cost driven. Because of increasing returns with density, a hub-and-spoke network allows the large carriers to benefit from substantial cost savings compared to a fully co...

With most major airlines operating a hub-and-spoke system and partnering with other airlines to offer code share flights, more and more passengers are required to make at least one connection before reaching their final destination. These trends in the airline industry have increased the percentage of transfer passengers. In order to minimize the number of missed connections and offer customers...

This paper presents a framework to analyze global alliances and mergers in the airline industry under competition. The framework can help airlines identify partners and network structures, and help governments predict changes in social welfare before accepting or rejecting proposed mergers or alliances. The research combines profit-maximizing objectives to cost-based network design formulations...

The disparity between the relative success of low-cost and network carriers since 2001 has often been attributed to the difference in route system architecture. This paper compares the economic and operational characteristics of point-to-point and hub-and-spoke route systems. It also argues that the emphasis placed on route structure obscures other differences in business models. Although U.S. ...

We study how the sequential formation of free trade areas affects trade flows between member countries. In a three-country, three-good model of comparative advantage if two countries have an FTA, and both sign a similar agreement with the third, trade between the two decreases. However, if only one of them signs an additional FTA, a huband-spoke pattern arises, and trade between the initial mem...