Brain metastases originate most commonly from carcinonoma of lung, breast, and colon and from melanoma. Therefore, metastatic adenocarcinoma to the brain are common metastatic brain tumor. Generally, metastatic adenocarcinoma in the brain appears low density on the non-enhanced computed tomography(CT). However, in very rare case mucin-containing metastatic adenocarcinoma show high density mimic...

New tetracyclic benzofurocoumarin (benzopsoralen) analogues were synthesized and their inhibitory effect on the growth of tumor cell lines was evaluated. The human tumor cell lines used were MDA MB231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma). The in vitro antitumor activity of the new benzopsoralens was discussed in terms of structu...

Breast metastasis from extra-mammary malignancy is not common. According to the literature, an incidence of 0.4-1.3% has been reported. We present three cases of metastasis to the breast from two pulmonary adenocarcinoma and one lung squamous carcinoma diagnosed concomitantly or metachronous with the primary tumor. Two pulmonary adenocarcinomas (a 43-year-old female and a 45-year old female) pr...

The Mucin 1 (MUC1) oncoprotein is aberrantly overexpressed in diverse human malignancies including breast and lung cancer. Although MUC1 modulates the activity of several transcription factors, there is no information regarding the effects of MUC1 on global gene expression patterns and the potential role of MUC1-induced genes in predicting outcome for cancer patients. We have developed an exper...

Shikonin, a small-molecule natural product which inhibits the activity of pyruvate kinase M2 (PKM2), has been studied as an anti-cancer drug candidate in human cancer models. Here, our results demonstrate that shikonin is able to sensitize human breast cancer cells to chemotherapy by paclitaxel (taxol). Human breast adenocarcinoma MBA-MD-231 cells, which have higher levels of PKM2 expression an...

BACKGROUND The transcription factor pituitary-1 (Pit-1) is mainly expressed in the pituitary gland, where it has critical roles in cell differentiation and as a transcriptional factor for GH and prolactin (PRL). It is also expressed in human extrapituitary tissues (placenta, lymphoid and haematopoietic tissues) and cell lines (human breast adenocarcinoma cells, MCF-7). Despite the widely sugges...

s 173 CHROMOSOMES, PLOIDY AND GENETIC IMBALANCES OF LUNG CANCER Iver Petersen Institute of Pathology, Charité Medical School, Humboldt University, Berlin, Germany Lung cancer is a heterogeneous and highly aggressive disease which is reflected by a wealth of genetic alterations on the DNA and RNA level. In an attempt to understand this apparent chaos we used screening methods like Comparative Ge...

Flax straw of flax varieties that are grown for oil production is a by product which represents a considerable biomass source. Therefore, its potential application for human use is of high interest. Our research has revealed that flax straw is rich in flavonoid C-glucosides, including vitexin, orientin, and isoorientin. The objective of this study was to evaluate the cytotoxicity and possible p...

Procyanidins have attracted some attention due to their demonstrated chemopreventive action, a relatively new and promising strategy to prevent cancer. Breast cancer is one of the leading causes of death in women worldwide and its treatment needs improvements. The aim of this work was to verify the procyanidin dimmer B2 cytotoxic effect to MCF-7 human breast cancer cells. MCF-7 cells were cultu...

Propolis is a resin formed by a complex mixture of chemical substances that bees collect from plants. Since ancient times, propolis has been used in folk medicine due to its biological properties that include antimicrobial, antioxidant, anti-inflammatory, and antitumoral activities. The aim of this study was to compare the in-vitro cytotoxic activities of 16 Cuban propolis extracts of different...