Multicentric Castleman’s disease (MCD) is a rare systemic lymphoproliferative disorder characterised by polylymphadenopathy, B-symptoms and classical lymph node histological findings. Hypercytokinemia, particularly interleukin-6 (IL-6), secondary to human herpes virus-8 (HHV-8) infection is key to the pathogenesis of MCD. However, MCD can occur independent of HHV-8 an entity known as idiopathic...

the name herpes comes from the greek herpein—“to creep.” Members of the Herpesviridae family have been identified in a variety of animals and they all share certain features, including an ability to establish latency following primary infection, as well as a potential to reactivate and cause further disease. Herpesviruses have large genomes and contain approximately 35 virion genes—all of which...

A 41-year old man, a previous parenteral drug user with negative serology for human immunodeficiency virus, and hepatitis B and C (HCV) viruses 1 year earlier, consulted for the progressive appearance of persistent asymptomatic lesions that had started to appear 6 months earlier in the left pectoral region; there were no accompanying extracutaneous symptoms. The patient reported no previous inf...

Herpes virus which ordinarily produces in Cebus olivaceus monkeys an acutely fatal encephalitis closely resembling in time, symptoms and pathology the acute, herpetic disease of rabbits may-in more resistant individual monkeys-lead to a more prolonged malady which, while unquestionably produced with herpes virus, simulates with considerable accuracy the human disease of acute encephalitis, in s...

Varicella zoster virus (VZV) is human neurotropic virus. It becomes latent in dorsal root ganglia; it may reactivate and can cause dermatological manifestations; most common herpes zoster. Several neurological disorders occur such as encephalitis, meningitis, myelitis neuropathy. Longitudinally extensive transverse infrequent.The association of AQP4 antibody with has been documented few case re...

The etiology of viruses in osteoarthritis remains controversial because the prevalence of viral nucleic acid sequences in peripheral blood or synovial fluid from osteoarthritis patients and that in healthy control subjects are similar. Until now the presence of virus has not been analyzed in cartilage. We screened cartilage and chondrocytes from advanced and non-/early osteoarthritis patients f...

We have developed and tested a method for printing protein microarrays on glass slides and using these microarrays in a comparative fluorescence assay to detect TORCH infections. We generated protein microarrays by printing antibodies to simultaneously determine infections of TORCH (toxoplasmosis-rubella-cytomegalovirus-herpes) by detecting antibodies against Toxoplasma gondii, rubella virus, c...

Results Of the 198 samples tested, 18 (9.09%) were positive to at least one of the three viruses, 10 (5.10%) were positive for EBV, 10 (5.10%) positive for CMV and 12 (6.10%) positive for HHV -6. According to age, we found that only those who had a less than or equal to 30 years old were infected. Infection with EBV, CMV and HHV-6 in women accounted for 8.57%, 8.57% and 11.43% respectively. Aga...