Although there is growing interest in the possibility that alterations in histone methylation may play a role in carcinogenesis, it has not been explored adequately in humans. Similarly, there are no reports of associations between this and a similar epigenetic event, DNA methylation. Using immunohistochemical staining, we compared the methylation of DNA and histones in histopathologically norm...

Objectives The objective of this study was to investigate the association between p53 expression and microbial acetaldehyde production in patients with oral squamous cell carcinoma (OSCC). Study Design Oral mucosal biopsies from 22 OSCC 24 healthy controls (HCs) were collected. analyzed by immunohistochemistry. Microbial samples collected mucosa ethanol measured gas chromatography. Results majo...

Candida albicans is the most frequent cause of oral fungal infections. However, the exact pathogenicity mechanisms that this fungus employs are largely unknown and many of the genes expressed during oral infection are uncharacterized. In this study we sought to functionally characterize 12 previously unknown function genes associated with oral candidiasis. We generated homozygous knockout mutan...

Overexpression of cyclooxygenase-2 (COX-2) plays an important role in development and progression of different human cancers, but the underlying molecular mechanisms remain to be defined. Tissue specimens of normal oral epithelia (n=9), dysplasia (n=38), and oral squamous cell carcinoma (SCC, n=54) were immunohistochemically analyzed for COX-2 and E2F-1 expression. A human oral SCC cell line, T...

Oral microbial flora refers to the population of microorganisms that inhabit skin and mucous membrane of the oral cavity of the normal healthy persons. The microbial cells in a human body outnumber the total number of cells in the human body 10 folds. The mouth harbors a diverse, abundant and complex microbial community on varied surfaces of the oral cavity including both hard and soft oral tis...

PURPOSE Autologous stem cell transplantation for total limbal stem cell deficiency is immunologically preferable, to avoid allograft rejection. This study was undertaken to investigate the possibility of a novel tissue engineering approach for ocular surface reconstruction, using autologous oral mucosal epithelial stem cells expanded ex vivo on temperature-responsive cell culture surfaces. ME...

Recent clinical studies on human skin indicated that in vivo multi-harmonic generation microscopy (HGM) can achieve sub-micron resolution for histopathological analysis with a high penetration depth and leave no energy or photodamages in the interacted tissues. It is thus highly desired to apply HGM for in vivo mucosa histopathological diagnosis. In this paper, the first in vivo optical virtual...

Peripheral ameloblastoma (PA) is a relatively uncommon odontogenic tumor that is histologically identical to the classic inttaosseous ameloblastoma but it occurs primarily in the soft tissues overlying the toothbearing regions of the jaws and does not exhibit the invasive and aggressive behavior of its intraosseous counterpart.l The origin of PA is thought to be from 1 of 2 sources: extraosseou...