Studies were performed to determine whether sympathetic nerves protect against stroke in hypertensive rats. The superior cervical ganglion was removed on one side in 28 stroke-prone spontaneously hypertensive rats (SHRSP) when the rats were 4 weeks old. The rats were fed Japanese rat chow and 1% saline drinking water. When the rats were 19 weeks old, systolic pressure was 206 +/- 4 mm Hg (mean ...

Background: Sparse data are available in literature about pattern of nasal affection in Sjogren syndrome (SS). Objective: To study the ultrastructural changes in the nasal mucosa in SS patients with nasal dryness. Methods: Light microscopy and transmission electron microscopy (TEM) of anterior end of inferior turbinate in 14 patients with SS experiencing nasal dryness and five healthy controls ...

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in many countries. The animal models that recapitulate human DN undoubtedly facilitate our understanding of this disease and promote the development of new diagnostic markers and therapeutic interventions. Based on the clinical evidence showing the association of eNOS dysfunction with advanced DN, we and others have creat...

The clinical introduction of the immunosuppressive drug cyclosporine in the early 1980s revolutionized the field of organ transplantation. The adoption of cyclosporine-based immunosuppressive regimens dramatically improved survival among patients who received nonrenal allografts. Twenty years later, cyclosporine and tacrolimus (another inhibitor of calcineurin — a key enzyme involved in T-cell ...

Introduction: Sarcoidosis is a granulomatous systemic disease. Renal damage rare but it can evolve to chronic renal failure (CRF). The aim of our work describe the clinical, paraclinical, histological and evolutionary profile involvement during sarcoidosis identify progression factors leading CRF. Materials Methods: This retrospective descriptive study from January 2009 December 2022. We collec...

thecosis include human immunodeficiencyvirus,leukemia,malignancies, hemodialysis, corticosteroid therapy, andcatheterization.Thepatientinthe currentstudywasreceivinglong-term immunosuppressivetherapyforgraftvs-hostdisease.Thesefactorslikelyled to the development of disseminated protothecosis. In summary, we present, to our knowledge, the first human case of choroiditis due to algae confirmed by...

Focal segmental glomerulosclerosis (FSGS) is characterized histologically by hyalinosis and sclerosis of glomeruli associated or not with podocyte involvement. The objective our work was to clarify the epidemiological aspects histological variants FSGS in C ôte d’Ivoire. Materials Methods: This a descriptive retrospective study, conducted from January 2015 December 2019 using renal biopsy regis...

Background: Diabetic nephropathy (DN) continues to be the leading cause of end-stage renal disease (ESRD) worldwide, and increased amount evidence supports that inflammation plays an important role in DN progression. Aim: Therefore, we aimed explore relationships between tubulointerstitial inflammatory cells infiltration kidney prognosis patients. Method: A total 384 Chinese participants with t...

The hand-foot syndrome (HFS) is an erythematous skin lesion of the palma and planta of the hand and feet is most often caused by cytostatic chemotherapy. The impact on the patients' quality of life depends on the extent of the disease. The pathogenesis of the hand-foot syndrome has not yet been sufficiently clarified and it can only be treated symptomatically. We performed an extensive literatu...

Acute postinfectious pityriasis rubra pilaris (PRP) is a variant of juvenile PRP (Griffiths type III) characterized by no family history, an acute course associated with a prior fever, and good prognosis. Clinical features may resemble other superantigen-mediated diseases, such as scarlatiniform rash or staphylococcal scalded skin syndrome, but its histology and treatment are different. We pres...