Abstract Controlled and targeted drug delivery systems consist of a carrier matrix one or more active ingredients. One the roles is to regulate release drug. Uptake, release, differential scanning microcalorimetry (DSC) powder X-ray diffraction (XRD) techniques were used reveal interactions governing dopamine indole from thermoresponsive model polymer gel. The can be completely recovered loaded...

The aim of the current study was to design sustained release matrix tablets of venlafaxine hydrochloride using ion exchange resin with the incorporation of hydrophilic and hydrophobic polymer combinations. Venlafaxine HCl was loaded onto Indion 244 by batch method and then resinate were wet granulated with ethyl cellulose and blended with hydroxypropylmethylcellulose and compressed. A central c...

Triphilic star-polyphiles are short-chain oligomeric molecules with a radial arrangement of hydrophilic, hydrocarbon and fluorocarbon chains linked to a common centre. They form a number of liquid crystalline structures when mixed with water. In this contribution we focus on a hexagonal liquid crystalline mesophase found in star-polyphiles as compared to the corresponding double-chain surfactan...

A commercial and very hydrophobic styrene-divinylbenzene matrix, MCI GEL® CHP20P, has been compared to octyl-Sepharose® beads as support to immobilize three different enzymes: lipases from Thermomyces lanuginosus (TLL) and from Rhizomucor miehie (RML) and Lecitase® Ultra, a commercial artificial phospholipase. The immobilization mechanism on both supports was similar: interfacial activation of ...

A reversible switchable on-demand UV-triggered drug delivery system (DDS) based on interpenetrating polymer networks (IPNs) with silicone as the host and spiropyran (SP)-functionalized guest is designed demonstrated. The photo-responsive IPNs provide a new triggered concept they exploit change in intermolecular interactions (work of adhesion) among drug, matrix, solvent when incorporated hydrop...

Persistent microbial contamination of medical implant surfaces is becoming a serious threat to public health. This principally due antibiotic-resistant bacterial strains and the formation biofilms. The development novel antibacterial materials that will effectively fight both Gram-positive Gram-negative bacteria prevent biofilm represents big challenge for researchers in last few decades. In pr...

in the present paper, we introduce the sequence space [{l_p}(e,delta) = left{ x = (x_n)_{n = 1}^infty : sum_{n = 1}^infty left|  sum_{j in {e_n}} x_j - sum_{j in e_{n + 1}} x_jright| ^p < infty right},] where $e=(e_n)$ is a partition of finite subsets of the positive integers and $pge 1$. we investigate its topological properties and inclusion relations. moreover, we consider the problem of fin...

Aligned amino acid sequences of three functionally independent samples of transmembrane (TM) transport proteins have been analyzed. The concept of TM-kernel is proposed as the most probable transmembrane region of a sequence. The average amino acid composition of TM-kernels differs from the published amino acid composition of transmembrane segments. TM-kernels contain more alanines, glycines, a...

The focus of the present work is to shed light on possible modifications of the molecular properties of polysaccharide hydrogels induced by the establishment of specific non-covalent interactions during the loading of a guest compound inside the gel phase. With this aim, a case study of the encapsulation of caffeine (Caf) inside cyclodextrin-based hydrogels, namely, cyclodextrin nanosponges (NS...