Gold nanoparticles (Au NPs) have been investigated for a number of biomedical applications, including drug and gene delivery vehicles, thermal ablation therapy, diagnostic sensors, and imaging contrast agents. Surface functionalization with molecular groups exhibiting calcium affinity can enable targeted delivery of Au NPs to calcified tissue, including damaged bone tissue. Therefore, the objec...

Calcium hydroxyapatite (HAp) is the main inorganic component of natural bones. In this review, the crystal structure and fabrication methods of HAp were first introduced; then the synthesis and applications of metal-ion-doped HAp nanoparticles were mainly reviewed. HAp was usually synthesized through solid state reaction and wet chemical precipitation, of which the properties depended on the fa...

The adverse biological effect of nanoparticles is an unavoidable scientific problem because of their small size and high surface activity. In this review, we focus on nano-hydroxyapatite and TiO₂ nanoparticles (NPs) to clarify the potential systemic toxicological effect and cytotoxic response of wear nanoparticles because they are attractive materials for bone implants and are widely investigat...

Some soluble phosphate salts, heavily used in agriculture as highly effective phosphorus (P) fertilizers, cause surface water eutrophication, while solid phosphates are less effective in supplying the nutrient P. In contrast, synthetic apatite nanoparticles could hypothetically supply sufficient P nutrients to crops but with less mobility in the environment and with less bioavailable P to algae...

Inhaled nanoparticles (NPs) must first interact with the pulmonary surfactant (PS) lining layer that covers the entire internal surface of the respiratory tract and plays an important role in surface tension reduction and host defense. Interactions with the PS film determine the subsequent clearance, retention, and translocation of the inhaled NPs and hence their potential toxicity. To date, li...

Magnetic adsorption is considered a promising technology for water treatment and solid–liquid separation. Porous magnetic Fe3O4-hydroxyapatite (wFeHAp) nanocomposites were prepared from Moroccan natural phosphate in the presence of Fe3O4 nanoparticles by controlled precipitation method. Their efficiency removal trace metals was tested. After treatment, separation wFeHAp powder carried out apply...

Biomineralization consists of a complex cascade phenomena generating hybrid nano-structured materials based on organic (e.g., polymer) and inorganic hydroxyapatite) components. is biomimetic process useful to produce highly biocompatible resembling natural hard tissues such as bones teeth. In detail, materials, composed hydroxyapatite nanoparticles (HA) nucleated an matrix, show extremely versa...

Abstract Insufficient mechanical properties of hydroxyapatite-based composites prompted the search for new and effective solutions dental applications. To improve without losing remineralization potential, use hybrid fillers was proposed. The first them based on formation hydroxyapatite (HA) layer surface SYLOID®244 silica. second investigated created by simultaneous synthesis nanoparticles fro...

The paper is focused on the formation of hydroxyapatite nanoparticles (HAp) in polyelectrolyte-modified microemulsions, in a microemulsion template phase consisting of cyclohexane, water, cationic surfactant and cosurfactant, in the presence of Na-polyacrylate (PAA) as an anionic polyelectrolyte. It is shown that PAA, can be incorporated into the individual inverse microemulsion droplets. The m...

aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (pcl), poly (vinyl alcohol) (pva) and hydroxyapatite nanoparticles (nha). the morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...