(+)-Amphetamine sulphate infused directly into the substantia nigra, pars compacta, at low rates and in low volumes and concentrations, produces a marked and prolonged inhibition of neuronal activity. This effect was significantly reduced or abolished following (+/-)-alphamethyl-p-tyrosine pretreatment or following electrolytic lesions in the diencephalon anterior to the substantia nigra. These...

As little is known about the neurotoxicity of histological structure brain, this study focuses on side four- to six-month-old adult Wistar rat brains, which were examined after 0.1 mg\g organophosphate had been administered orally. In study, lesions mainly localized at hippocampus and substantia nigra (compacta pars) region. Distinct areas necrotic apoptotic tissues detected in CA1, CA2, dentat...

Liquid column chromatography, planar chromatography (TLC) on modified and unmodified silica layers, reversed-phase high-pressure liquid chromatography (HPLC), as well as ESI-TOF MS and 1H-NMR have been used for separation, purification and identification of phenolic acids in the barks of Sambucus nigra and Viburnum opulus (Caprifoliaceae). By the use of these procedures three cinnamic acid deri...

Reduced and oxidized glutathione concentrations in post-mortem brain tissue from the substantia nigra of control subjects and patients with neuropathologically confirmed Parkinson's disease were measured by a coulometric method using high-pressure liquid chromatography and electrochemical detection. Reduced glutathione concentrations were decreased in the substantia nigra of parkinsonian patien...

Cortical epileptic focus was produced by an intracortical injection of FeCl3 in rat cerebral cortex using standard techniques. How after its onset in the cortical focus, the epileptiform activity evolved with time in the thalamus and substantia nigra has been determined. To study the propagation of the epileptiform activity, the local EEG and multiple unit action potentials were recorded from t...

Tinea nigra is a rare superficial mycosis caused by Hortaea werneckii. This infection presents as asymptomatic brown to black maculae mostly in palmo-plantar regions. We performed scanning electron microscopy of a superficial shaving of a tinea nigra lesion. The examination of the outer surface of the sample showed the epidermis with corneocytes and hyphae and elimination of fungal filaments. T...

The effect of repeated administration of 3,4-methylenedioxymethamphetamine (MDMA) on the expression of tyrosinc hydroxylase and preprocholecystokinin (CCK) messenger RNAs in substantia nigra was examined by in situ hybridisation histochemistry. Sections hybridised with 35S-labelled oligonucleotides were subjected to computerised image analysis to determine the densiw of silver grains above posi...

The research focuses on the effects of polyphenols extracted from Sambucus nigra fruit, using an experimental arterial hypertension pattern, as well as their influence on the oxidative stress. The results reveal the normalization of the reduced glutathion concentration, as well as a considerable reduction in the malondialdehide serum concentration by the polyphenolic protection. The rat blood p...

Ascidians are involved with rich source of bioactive agents which could be used for novel antimicrobial drugs. Ascidians are belongs to phylum chordate and class Ascidiacea. In present study two ascidians P. madrasensis and P. nigra were collected from Tuticorin, Southeast coast of India. The antibacterial compounds were screened to evaluate antibacterial activity in and different solvent like ...

Parkinson's disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of this cell death is unknown. Homocysteine (Hcy) is a non-protein amino acid. It is a homologue of the amino acid cysteine. The elevated levels of homocysteine in p...