The synthesis and characterisation of two groups nonsymmetric dimers, the 1-(4-cyanobiphenyl-4‘−yloxy)-ω-(4-butyl, 4-(1-methylpropyl) or 4-t-butylanilinebenzylidene-4’−oxy)alkanes, 1-(4-cyanobiphenyl-4‘−yl)-ω-(4-butyl, are reported. length parity flexible spacer is varied. tert-butyl homologues show higher melting points than corresponding sec-butyl n-butyl substituted suggesting that chain bra...

This work concerns the effect of fillers and ionic liquids on cure characteristics natural rubber (NR) compounds, as well mechanical thermal properties vulcanizates. Three types white filler were applied, such cellulose, nanosized silica hydrotalcite, to modify performance NR composites. Additionally, (ILs) with bromide anion different cations, i.e., 1-butyl-3-methylimidazolium (Bmi) 1-butyl-3-...

A methyl ketone, an aryl bromide, an electrophile, and ammonium chloride were combined in a four-component, three-step, and one-pot coupling procedure to furnish substituted isoquinolines in overall yields of up to 80%. This protocol utilizes the palladium catalyzed α-arylation reaction of an enolate, followed by in situ trapping with an electrophile, and aromatization with ammonium chloride. t...

The acute intravenous toxicities of a selection of three potential long-acting local anaesthetics belonging to the series of2- phenoxyethyldialkylamine were determined in mice. Two of the compounds were tertiary amines and the third a quaternary ammonium derivative.The I.V. median lethal dose, (LDso) of one of the tertiary compounds, 21A [N, N- diethyl-2- (2,6- diisopropyl) ethyl amine hyd...

A new cyclic nitrone spin trap, [4-(3',3'-dibutyl-2'-oxy-3'H-isoindol-5'-yloxy)butyl]triphenylphosphonium bromide (MitoSpin), bearing a lipophilic cation has been prepared by a route that involves a novel Parham-type lithiation-cyclization of an isocyanate to give the isoindolinone core. MitoSpin accumulates in a membrane potential dependent way in energized mitochondria and its oxidation could...

Use of anticholinergic drugs in treatment of duodenal ulcers is limited by the side effects of widespread parasympathetic blockade evoked by usual therapeutic doses. A study. was conducted into the effectiveness of transdermal delivery of hyoscine methobromide using a new system which releases the drug into the circulation at a controlled rate. In six patients whose duodenal ulcer had healed se...

In the title compound, (C8H12N)3[SnBr6]Br, the anilinium N atom of one of the three unique cations exhibits flip-flop disorder with an 0.60:0.40 occupancy ratio. In the crystal, N-H⋯Br hydrogen bonds link the N,N-di-methyl-anilinium cations and both Br(-) anions and [SnBr6](2-) dianions into a layered arrangement parallel to (001).

volatile constituents of the seed kernel and leaf of cultivated moringa peregrina (forssk.) fiori, agricolt collected after hydrolysis were analyzed by gc and gc/ms. five glucosinolate degradation products which constituted almost the whole isolated oil of the seed kernel were identified to be: isobutyl isothiocyanate (94.0%), isopropyl isothiocyanate (4.9%), sec-butyl isothiocyanate (0.5%), n-...