Background: The efficacy of cuttlebone for treating hyperphosphatemia in patients with end-stage renal disease and its safety remained unclear. Methods: Randomized controlled trials comparing the conventional interventions were retrieved from MEDLINE, EMBASE, Cochrane Library, Airiti other major Chinese databases until 1 February 2023. primary outcome was circulating phosphate concentration, wh...

キーワード:ビキサロマー,リン酸結合性ポリマー,高リン血症,膨潤,消化器副作用 アステラス製薬株式会社 研究本部 薬理研究所(〒305 -8585 茨城県つくば市御幸が丘 21) E-mail: [email protected] 原稿受領日:2013 年 1 月 18 日,依頼原稿 Title: Pharmacological and clinical profile of bixalomer (Kiklin capsules): a new therapeutic agent for hyperphosphatemia Author: Keiichi Taniguchi, Hirotoshi Kakuta, Yuichi Tomura, Seiji Kaku, Wataru Uchida 要約:ビキサロマー(キックリンカプセル)はリン 酸吸着ポリマーであ...

Main Findings: Hyperphosphatemia constitutes a major stimulus for FGF-23 secretion, together with infl ammation and reduced iron availability, either by iron defi ciency or by iron sequestration in infl ammatory diseases. FGF-23 can be expressed by the damaged liver. Alcoholism is a proinfl ammatory condition, and in alcoholics there is an increased cardiovascular risk. Preliminary data suggest...