نتایج جستجو برای: hyperpolarization activiated current if sino atrial node
تعداد نتایج: 1634876 فیلتر نتایج به سال:
Acute dilation of the right atrium (e.g., via increased venous return) raises spontaneous beating rate (BR) of the heart in many species. Neural mechanisms contribute to this behavior in vivo, but a positive chronotropic response to stretch can also be observed in isolated right atrial tissue preparations and even at the level of single sino-atrial node (SAN) cells. The underlying mechanism has...
Early development of ionic models for cardiac myocytes, from the pioneering modification of the Hodgkin-Huxley giant squid axon model by Noble to the iconic DiFrancesco-Noble model integrating voltage-gated ionic currents, ion pumps and exchangers, Ca(2+) sequestration and Ca(2+)-induced Ca(2+) release, provided a general description for a mammalian Purkinje fibre (PF) and the framework for mod...
AIMS This study aimed at characterizing expression and the functional role of the Gjb6 gene, encoding for connexin 30 (Cx30) protein, in the adult mouse heart. METHODS AND RESULTS The expression of the Gjb6 gene in the mouse heart was investigated by RT-PCR and sequencing of amplified cDNA fragments. The sites of Gjb6 expression were identified in the adult heart using transgenic mice with re...
Aside from the nerve fibers which enter the pace-making node from the subepicardium, there were observed within the limits of the node a few ganglionic cells and a plexus of moniliform nerve fibrils in very close relation to its muscle fibers, hence the sino-auricular node, like the auriculo-ventricular, may be considered from a histological standpoint a neuromuscular organ.
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