The aims of this study are to describe the mean values of carotid intima-media thickness and how it increases with age, and to compare carotid injury in diabetics and hypertensive patients with that of controls. We included 562 subjects (121 diabetics, 352 hypertensive patients, 89 controls). The mean intima-media thickness was 0.781 mm in diabetics, 0.738 mm in hypertensive patients and 0.686 ...

The hypotensive action of CV-4093.2HCl (CV-4093), a new calcium antagonist, was studied in spontaneously hypertensive, renal hypertensive, DOCA-salt hypertensive and normotensive rats. CV-4093 (3 and 10 mg/kg, p.o.) dose-dependently decreased systolic blood pressure in the three types of hypertensive rats. At the dose of 10 mg/kg, the compound decreased the blood pressure to the normotensive le...

The startle response, consisting of behavioral and cardiovascular components, was used to study the reaction of the cardiovascular system to a mild environmental stressor. We used tactile air puff startle to study responses in adult Wistar-Kyoto and spontaneously hypertensive rats. In both strains, air puff elicits a transient motor response with rapid habituation over the test session of 30 tr...

BACKGROUND Hypertension is one of the most important risk factors for atrial fibrillation (AF). Recent studies suggest right atrial remodeling in hypertensive patients may be associated with increased inducibility of AF. This study sought to characterize the electroanatomic features of left and right atria and pulmonary veins (PVs) in hypertensive patients. METHODS AND RESULTS A prospective o...

OBJECTIVES Whilst hypertension exerts a negative effect on several organs there have been few studies regarding its effect on pulmonary function. The objective of this study was to examine the relationship between hypertension and pulmonary function in rural Korean adults. METHODS In 2006, 2534 people were recruited, aged 40 to 70, in Kangwha County. We selected 1454 (male: 624, female: 830) ...

the purpose of this prospective study was to determine the effect of calcium supplementation in the incidence of hypertensive disorders of pregnancy (gestational hypertension and pre-eclampsia) in nulliparous and high risk women. 300 pregnant women in the 24th week of gestation at the beginning of the study were entered into a double-blind randomized trial. 143 of them who had a positive roll-o...

It has been established that deoxycorticosterone acetate (DOCA)-salt hypertensive rats have an overactive brain angiotensin-system. The purpose of the present study was to identify the brain sites showing enhanced angiotensin-system activity responsible for the pathogenesis of hypertension in DOCA-salt hypertensive rats. The angiotensin receptor antagonist, losartan, was injected into brain ven...