Di(4-nitrobenzoyloxy)iodo]benzene (1), a hypervalent iodine compound, is easy to prepare and stable as solid, was shown be useful functional group transforming agent in this report. Oxidative synthesis of symmetrical disulfides from thiols the presence compound 1 alone performed 58–100% yields. Furthermore, ESI-MS demonstrated that premixing Ph3P yields corresponding acyloxyphosphonium, which c...

Described herein is a divergent continuous-flow approach for the biomimetic oxidative cyclization of reticuline-type alkaloids to aporphine and morphinandienone natural products using hypervalent iodine(III) reagents. The method was based on detailed knowledge reaction mechanisms in order develop robust conditions toward selective synthesis either or products. In this frame, we exploited abilit...

8β-Hydroxy-9(11),13-abietadien-12-one (1), an abietane diterpenoid and aryl hydrocarbon receptor (AhR) ligand, was synthesized in six steps from commercially available (+)-dehydroabietylamine (2). We used the hypervalent iodine catalyst phenyliodine dicarboxylate, a safer alternative to toxic organoselenide reagents, for oxidative dearomatization of ferruginol (7) compound 1. Compounds 1 2, as ...

The front cover picture, designed by Yoshimura, illustrates applications of benziodoxoles as group transfer reagents. Cyclic hypervalent iodine compounds based on the benziodoxole system have higher stability compared to their acyclic analogues, which makes possible preparation and safe handling reagents with special ligands such azido, cyano, trifluoromethyl groups. Substituted been widely uti...