In the literature, there are some data which indicate that benzodiazepines and other chemical compounds with the same mechanism of action (Diazepam, Chlordiazepoxide, Lorazepam, Zopiclone, etc.) also have other effects. We investigated the effects of experimental chronic inflammation under the administration of some tranquilizers and hypnotics on peripheral algesia induced in rats by "writhing ...

Results. The effect of ketamine had a de®nite daily variation in wild-type mice. No signi®cant difference in blood concentration was observed at different dosing times (10:00 and 22:00). In NMDA receptor e1 KO mice, the hypnotic effect of ketamine was weaker than in wild-type mice and there was no dependence on the time of administration. Signi®cant pharmacokinetic differences were not observed...

Hypnosis can profoundly alter sensory awareness and cognitive processing. While the cognitive and behavioral phenomena associated with hypnosis have long been thought to relate to attentional processes, the neural mechanisms underlying susceptibility to hypnotic induction and the hypnotic condition are poorly understood. Here, we tested the proposal that highly hypnotizable individuals are part...

OBJECTIVE The present study was designed to test the hypotheses that response expectancies and emotional distress mediate the effects of an empirically validated presurgical hypnosis intervention on postsurgical side effects (i.e., pain, nausea, and fatigue). METHOD Women (n = 200) undergoing breast-conserving surgery (mean age = 48.50 years; 63% White, 15% Hispanic, 13% African American, and...

OBJECTIVE To compare how newly initiated treatment with benzodiazepines, Z-hypnotics or both associates with the reception of disability pension among 40,661 individuals of a working age. DESIGN Prescription register study. SETTING Norwegian nationwide prescriptions socio-economic and disability status data. METHODS Cox regression analyses. SUBJECTS New benzodiazepine or Z-hypnotic user...

The phenomenon of hypnotic anaesthesia has been well established for over a century, since Esdaile (1846) published his original account of 73 surgical operations carried out painlessly under hypnosis, and the technique has established a modest, but definite, place in contemporary medicine and dentistry (Mason, 1960, 1964). In view of this, it is surprising how little is known of the physiology...

Hypnotic suggestions designed to induce a sensation of pain were given to 11 highly hypnotizable participants and produced the intended effect in six of them. Subjective aspects of the pain experiences were investigated using conventional pain questionnaires and a multidimensional scaling technique. The implications are discussed in terms of a model of consciousness and the etiology of chronic ...

The effect of hypnotic suggestion of naturally occurring and experimentally induced psychologic stress on the respiratory system was studied in 11 young male subjects. It was found that hypnotic suggestion of deep relaxation and depression formed one end of the spectrum, while suggestion of exercise, anger, and anxiety formed the other end. Patterns of response in the first group were called no...