The application of stevia glycosides in the food industry has grown steadily last two decades. Besides use its constituents as natural sweeteners, increasing attention been given to their potential health benefits and therapeutic applications. Whereas some cases clinical studies have realized (prominently, investigate hypoglycemic antihypertensive activity) many them failed cover expectations f...

Objective(s): Oxidative stress has a pivotal role in the pathogenesis of diabetic retinopathy (DR). Juglans regia L. (JRL) leaf extract has hypoglycemic and antioxidative properties. This study aimed to determine the ameliorative effects of JRL against diabetic retinopathy. Materials and Methods: The DR rat model was generated by injection of streptozotocin (STZ). A subset of the diabetic rats ...

Total sleep deprivation (TSD) exerts strong modulatory effects on the secretory activity of endocrine systems that might be related to TSD-induced challenges of cerebral glucose metabolism. Here, we investigate whether TSD affects the course of male pituitary-gonadal and pituitary-thyroid axis related hormones during a subsequent 240-min hypoglycemic clamp. Ten healthy men were tested on 2 diff...

BACKGROUND The active components of Gardenia (Gardenia jasminoides Ellis, GJ) exhibit a hypoglycemic effect by improving insulin secretion and lowering plasma lipids. In the present study, we fed a water extract of gardenia to steroid-induced insulin-resistant (SIIR) rats and observed changes in signaling proteins in order to elucidate the mechanisms of the insulin-sensitizing effect of GJ and ...

Myricetin is a common plant-derived flavonoid and exhibits wide range of activities. However, myricetin also substantial limitations, such as its poor water-solubility low stability in body when it was administrated orally. To solve these problems, series derivatives with different disaccharide groups were designed, synthesized evaluated their hypoglycemic All compounds displayed significant ?-...

OBJECTIVE The objectives of the study are to screen out various phytochemicals and to evaluate the antioxidant and antidiabetic potential of the stem bark of Holarrhena pubescens Wall (Holarrhena antidysenterica). MATERIALS AND METHODS The antioxidant activity was determined by the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity where ascorbic acid was taken as positive contr...

PURPOSE Reports of serial magnetic resonance imaging (MRI) in hypoglycemic encephalopathy were limited because MRI is not routinely performed in these patients. Here we present one patient with a history of hypoglycemic encephalopathy and discuss sequential neuroimaging findings. CASE REPORT A 53-year-old male mistakenly took oral hypoglycemic agents developed hypoglycemic encephalopathy. Imm...