نتایج جستجو برای: hypogonadotropic hypogonadism
تعداد نتایج: 3749 فیلتر نتایج به سال:
DAX-1 [dosage-sensitive sex reversal, adrenal hypoplasia congenital (AHC) critical region on the X chromosome, gene 1] is a transcription factor expressed in the adrenal gland and at all levels of the gonadotrope axis. Inactivating mutations of DAX1 result in the X-linked form of AHC with associated hypogonadotropic hypogonadism. AHC usually reveals itself as adrenal failure in early infancy, a...
Congenital hypogonadotropic hypogonadism (CHH) is an insufficient production of sex hormones due to loss of hypothalamic–pituitary–gonadal axis control. it is referred to as combined deficiency when it is associated with impairment of other endocrine axes. Signs of congenital hypogonadotropic hypogonadism are micro penis, delayed puberty in adolescence and infertility in adulthood. Abnormal sex...
Kallmann syndrome (KS) is a clinically and genetically heterogeneous disorder. Recently, loss-of-function mutations in the fibroblast growth factor receptor 1 (FGFR1) gene have been shown to cause autosomal dominant KS. To date, the detailed reproductive phenotype of KS associated with mutations in the FGFR1 has yet to be described. We report a kindred comprising a male proband with KS and spon...
Mice lacking ALK activity have previously been reported to exhibit subtle behavioral phenotypes. In this study of ALK of loss of function mice we present data supporting a role for ALK in hypogonadotropic hypogonadism in male mice. We observed lower level of serum testosterone at P40 in ALK knock-out males, accompanied by mild disorganization of seminiferous tubules exhibiting decreased numbers...
Idiopathic hypogonadotropic hypogonadism (IHH) with anosmia (Kallmann syndrome; KS) or with a normal sense of smell (normosmic IHH; nIHH) are heterogeneous genetic disorders associated with deficiency of gonadotropin-releasing hormone (GnRH). While loss-of-function mutations in FGF receptor 1 (FGFR1) cause human GnRH deficiency, to date no specific ligand for FGFR1 has been identified in GnRH n...
Estrogen-secreting adrenal cancers are extremely rare, with feminizing symptoms attributed to aromatase expression in the adrenal tumor. We describe a case of hypogonadotropic hypogonadism as a consequence of aberrant aromatase expression in a patient with adrenocortical adenocarcinoma. A 54 year-old man presented with a two month history of gynecomastia and reduced libido. Endocrine biochemist...
BACKGROUND The prevalence of hypogonadism in HIV-infected patients is still a matter of debate as there is no standardized consensual diagnostic method. In addition, the etiology and endocrine/metabolic implications of hypogonadism in this population remain controversial. This study aims to determine the prevalence of testosterone deficiency in a single-site hospital and to evaluate its associa...
Background: Thalassemia is the most common cause of chronic hemolytic anemia and correlated with significant morbidity mortality. Osteoprotegerin (OPG) an ? tumor necrosis factor receptor superfamily glycoprotein that acts as a decoy for activator nuclear kappa B ligand (RANKL), exerting antiresorptive bone effect also play critical roles in hypogonadism associated osteoporosis. Objective: Toe...
SUMMARY We studied the chronic effect of chemical gases on pituitary-gonad axis of victims of Iran and Irag war. The patients that their poisoning were higher than three years, selected. After clinical evaluation, and role out of systemic disease 168 victims were tested for testosterone, follicular stimulating hormone and leutinizing hormone. Comparison of results control group (n=200) and wi...
OBJECTIVE To determine the effect of lipid/heparin versus saline infusion, with or without concurrent euglycemic hyperinsulinemia, on serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Obesity is associated with hyperlipidemia, insulin resistance, and relative hypogonadotropic hypogonadism. It was hypothesized that acutely elevated fatty acids and insulin would impair gonado...
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