Progesterone, total oestrogens (mainly conjugated and unconjugated oestrone), prolactin and placental lactogen have been determined during late pregnancy in the peripheral plasma of intact or hypophysectomized ewes after destruction of the foetal pituitary. During the prolongation of gestation due to the removal of the foetal hypophysis, progesterone and placental lactogen remained at a high le...

y-Glutamyltranspeptidase, Prolactin, Estradiol (Rat Mammary Gland) 1. The in vivo effect of estradiol and domperidone (a hypophysis stimulator of prolactin secre­ tion) in immature ovariectom ized-adrenalectom ized and hypophysectomized rat mammary gland was studied. 2. y-Glutamyltranspeptidase activity was used to evaluate the role of estradiol in the specific response of the gland to prolacti...

It is not many years since the medical world was intrigued by the work done and proofs shown regarding the omnipotence of the thyroid gland. It was called ' the sun round which the body rotated' the draught to the fire' the sparking plug of human metabolism', terms comprehensive and doubtless correct. Now in this small volume Professor Graves sets out to review and make clear the romance of the...

The aim of this study was to perform an immunohistochemical study of the angiotensinergic pathway from the arcuate nucleus (AN) to the posterior lobe of the hypophysis (PLH) of 10week-old matched normotensive Wistar Kyoto rats (WKY), using our own policlonal antibody raised in mice against Angiotensin II (mouseantiangiotensin II, MAAII). Cells and fibers in the rostroventral and dorsocaudal par...

Deamination is one step in the metabolism of amino acids. This process is catalyzed by the Dand L-amino acid oxidases. It is known that various endocrine secretions will affect the rate of enzymatic reactions. The present communication presents data on the interrelation of amino acid concentration in the blood and the secretions of the hypophysis, adrenal, and thyroid on the rate of activity of...

The LH-immunoreactive cells of the adult rat hypophysis were studied morphometrically after chronic treatment with methoclopramide. The morphological features of these cells showed modifications in both male and female rats, after treatment. Additionally, morphometric changes revealed a significant decrease (p less than 0.05) in both cytoplasmic area, which was more evident in the female rats, ...

JEFFERSON, M. & ROSENTHAL, F.D. (1959) Spontaneous necrosis in pituitary tumour. Lancet, i, 342. KIRSHBAUM, J.D. & CHAPMAN, B.M. (1948) Subarachnoid hemorrhage secondary to a tumor of the hypophysis with acromegaly. Annals of Internal Medicine, 29, 536. LOPEZ, I.A. (1970) Pituitary apoplexy. Journal of the Oslo City Hospital, 20, 17. MEADOWS, S.P. (1968) Unusual clinical features and modes of p...

[N the routine examination of some seven hundred brains, seven were found to have shown the clinical syndrome of diabetes insipidus (Biggart, 1935, 1936, and 1937). Whilst the anatomical findings in these seven cases allow of the interpretation of the pathogenesis of the diabetic syndrome on the basis of the destruction of the (1) supraoptic nuclei, or (2) the supraoptic-hypophyseal tract, or (...

1. Perfusion of isolated thyroid glands from rabbits, made refractory to the action of the thyro-stimulating factor from the hypophysis by repeated injections for 2 months, has shown that in this condition the thyroid epithelium responds to pituitary stimulation. 2. The serum from refractory rabbits does not neutralize completely the thyro-stimulating effect of anterior pituitary extract upon a...