The objective of the present study was to examine whether hypothyroidism affects the reproductive system of adult female rats by evaluating ovarian morphology, uterus weight and the changes in serum and pituitary concentrations of prolactin and gonadotropins. Three-month-old female rats were divided into three groups: control (N = 10), hypothyroid (N = 10), treated with 0.05% 6-propyl-2-thioura...

The present study was undertaken to investigate the effects of thyroid deficiency on cerebellar development with mouse endocrine genetic models. Four types of mutant mice, the growth hormoneand thyroid hormone-deficient Snell dwarf mouse (dwldw), the growth hormone-deficient little mouse (/it//if), the primary hypothyroid mouse (hytlhyf), and the congenital goiter mouse (cog/cog) were analyzed ...

Background: Hypothyroidism, one of the most common endocrine disorders, may induce neurological abnormalities at an early stage of the disease. Aim: The study was designed to assess the electrophysiological alterations of some selected variables of nerve conduction, brainstem auditory evoked potentials (BAEPs), and visual evoked potentials (VEPs) in hypothyroid patients. Subjects and Methods: S...

Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone or, more rarely, from their impaired activity at tissue level. This study was designed to estimate the Creatine phosphokinase, serum creatinine level and estimated glomerular filtration rate in hypothyroidism cases and to assess the correlation with T4 and TSH. This Study included 62 patients of hypothyro...

Respiratory symptoms in infants with hypothyroidism were not emphasized as an integral part of the clinical picture until Lowrey, Aster, Carr, Ramon, Beierwaltes and Spafford (1958) pointed out the frequency with which such symptoms occurred. Of their cases, 75% had various degrees of respiratory difficulty. The purpose of this report is to draw attention once more to the frequency of respirato...

1. Urinary excretion of digoxin-like immunoreactive factor and arginine-vasopressin and other parameters related to salt and water metabolism were studied in hyper- and hypo-thyroid rats after different tests. 2. Urinary excretion of arginine-vasopressin was increased in hyperthyroid and reduced in hypothyroid rats with respect to controls, in response to water deprivation or a hypertonic salin...

Abnormalities of carbohydrate metabolism in hyperthyroid patients have been long noted. Elevated proinsulin level is considered as an early marker of B-cell impairment. Proinsulin levels in hyperthyroid patients decreased after antithyroid drug therapy. However, proinsulin in hypothyroid patients was only rarely reported, and the difference was only demonstrated after glucose stimulation-there ...

Hypothyroidism induces several metabolic changes that allow understanding some physiopathological mechanisms. Under experimental hypothyroid conditions in rats, heart and kidney are protected against oxidative damage induced by ischemia reperfusion. An increased resistance to opening of the permeability transition pore seems to be at the basis of such protection. Moreover, glomerular filtration...

This study assessed salt sensitivity, analyzing the effects of an increased saline intake on hemodynamic, morphological, and oxidative stress and renal variables in experimental thyroid disorders. Six groups of male Wistar rats were used: control, hypothyroid, hyperthyroid, and the same groups treated with salt (8% via food intake). Body weight, blood pressure (BP), and heart rate (HR) were rec...