BACKGROUND Dyspeptic symptoms are commonly reported complaints in clinical practice and are mostly the result of functional disorders. Empirical treatment with histamine H2-receptor blockers or gastroprokinetics for 2-4 weeks has frequently been proposed as first line management of these patients. The clinical trials which support the use of these agents, show a high variation in clinical succe...

AIM To determine if botulinum toxin type A (BoNT-A) injections can reduce the frequency and severity of migraines. METHODS Patients (n = 127) were randomized to receive placebo or two doses of BoNT-A (Dysport). The primary endpoint was reduction in number of migraine attacks up to week 8 and between weeks 8 and 12 after injection. Patient diaries were used to record secondary endpoints, inclu...

The use of cinnamon as a spice and flavouring agent is widespread throughout the world. Many different species of plants are commonly referred to as 'cinnamon'. 'True cinnamon' refers to the dried inner bark of Cinnamomum verum J. S. Presl (syn. C. zeylanicum) (Lauraceae). Other 'cinnamon' species, C. cassia (Nees & T. Nees) J. Presl (syn. C. aromaticum Nees) (Chinese cassia), C. loureiroi Nees...

Sub-optimal functioning of the dorsal prefrontal cortex is associated with executive dysfunction, such as set-shifting deficits, in neurological and psychiatric disorders. We tested this hypothesis by investigating the effect of low-frequency 'inhibiting' off-line repetitive transcranial magnetic stimulation (rTMS) on the left dorsal pre-frontal cortex on behavioural performance, neural activit...

BACKGROUND Adverse effects such as fatigue, pain, erythema, nausea and vomiting are commonly known in patients undergoing irradiation (RT) alone or in combination with chemotherapy (RCHT). Patients suffering from these symptoms are limited in their daily life and their quality of life (QOL) is often reduced. As addressed in several trials, acupuncture can cause amelioration of these specific di...