We use a general equilibrium model to address the question whether a regulatory emission standard or an emission tax yields higher societal welfare for any given target on aggregate emission. The key feature of the model is that the plants are heterogeneous in productivity and monopolistically competitive in the production of dirty-goods whose by-product is emission. We …nd that the standard yi...

We present a simple model of the macroeconomy that includes a role for an assetprice bubble, and derive optimal monetary policy settings for two policy-makers. The first policy-maker, a sceptic, does not attempt to forecast the future possible paths for the asset-price bubble when setting policy. The second policy-maker, an activist, takes into account the complete stochastic implications of th...

Colicin E3 is a cytotoxic ribonuclease that specifically cleaves 16S rRNA at the ribosomal A-site to abolish protein synthesis in sensitive Escherichia coli cells. We have performed extensive mutagenesis of the 96-residue colicin E3 cytotoxic domain (E3 rRNase), assayed mutant colicins for in vivo cytotoxicity, and tested the corresponding E3 rRNase domains for their ability to inactivate ribos...

Purpose- Lately after the occurrence of Covid-19, there has been a substantial wave foreign aid funds from developed to developing economies aimed back up most effected countries. The concept aids with primary goal eradicate poverty is not new economy and social development scholars since it researched for decades. Methodology- eradication was adopted what so called Millennium Development (1990...

PURPOSE The development of photoreceptor replacement therapy for retinal degenerative disorders requires the identification of the optimal cell source and immunosuppressive regimen in a large animal model. Allotransplants are not acutely rejected in swine subretinal space, although it is not known if survival can be improved with immunosuppression. Here we investigated the survival and integrat...

This paper studies the state-dependent effects of shocks to distortionary tax rates in a dynamic stochastic general equilibrium (DSGE) model augmented with a number of real and nominal frictions. The tax output multiplier is defined as the change in output for a one dollar change in tax revenue caused by a shock to distortionary tax rates on consumption, labor income, or capital income. We find...

The interest in integrase-defective lentiviral vectors (IDLVs) stems from their potential advantage of large cloning capacity and broad cell tropism while avoiding the possibility of insertional mutagenesis. Here, we directly compared the transducing potential of IDLVs based on the equine infectious anemia virus (EIAV) to the more commonly described HIV-1 IDLVs. IDLVs were constructed by introd...

A long-term sodium nitrite infusion is intended for the treatment of vascular disorders. Phase I data demonstrated a significant nonlinear dose-exposure-toxicity relationship within the therapeutic dosage range. This study aims to develop a quantitative systems pharmacology model characterizing nitric oxide (NO) metabolome and methemoglobin after sodium nitrite infusion. Nitrite, nitrate, and m...

Immigration is often seen as an instrument of adaptation for aging countries. In this paper, we evaluate, using a dynamic general equilibrium model, the contribution of migration policy in reducing the tax burden associated with the aging population in France. Four alternative scenarios, compared to a baseline scenario based on official projections, are simulated with the aim to quantify the im...

The transport systems are dependent on the fossil fuels especially liquid fuels and these fuels are depleting at much faster rate than production. The consumption of fossil fuels is very unstable and directly affects the economy of our country as we are importing it from other nations so this factor has urged us to find other alternatives to prolong the usage of petroleum. Thus, by using bio-fu...