Treating HIV is made difficult by the evolution of antimicrobial resistant mutants that occurs in life cycle this virus. This has led to numerous inhibition mechanism intends challenges replication One such approach application molecular modelling drug discovery. In study computer aided design were employed finding an inhibitor can contribute a suitable candidate. Firstly, ZINC database was scr...

Background: Heart failure (HF) and ischemic heart diseases (IHD) are important causes of death in Brazil. Objective: To assess proportional mortality (PM) due to HF and IHD as underlying causes stratified by sex and age groups in the Brazilian geoeconomic regions from 2004 to 2011. Methods: Data from death certificates were obtained in the DATASUS site under the following International Stat...

Background Growing evidence suggests a role of exposure to chemicals and industrial pollutants, such as hydrocarbons, silica, mercury, organochlorines trichloroethylene, particulate air pollution, UV radiation, infectious agents, living in certain geographic regions, sociodemographic factors increasing the risk and/or affecting outcome systemic lupus erythematosus (SLE). We utilized environment...

Entry into the hypometabolic state of estivation requires a coordinated suppression of the rate of cellular ATP turnover, including both ATP-generating and ATP-consuming reactions. As one of the largest consumers of cellular ATP, the plasma membrane Na+/K+-ATPase is a potentially key target for regulation during estivation. Na+/K+-ATPase was investigated in foot muscle and hepatopancreas of the...

Isoxadifen-ethyl can effectively alleviate nicosulfuron injury in the maize. However, the effects of safener isoxadifen-ethyl on detoxifying enzymes in maize is unknown. The individual and combined effects of the sulfonylurea herbicide nicosulfuron and the safener isoxadifen-ethyl on the growth and selected physiological processes of maize were evaluated. Bioassays showed that the EC50 values o...

BACKGROUND Circulatory system diseases are the first cause of death in Brazil. OBJECTIVE To analyze the evolution of mortality caused by heart failure, by ischemic heart diseases and by ill-defined causes, as well as their possible relations, in Brazil and in the geoeconomic regions of the country (North, Northeast, Center-West, South and Southeast), from 1996 to 2011. METHODS Data were obt...

Respiring mitochondria drive the electrophoretic uptake of K+ and other cations. In the presence of permeant acids this transport leads to mitochondrial swelling if it is not compensated by electroneutral K+/H+ exchange mediated by the K+/H+ antiporter. The mechanism of influx has yet to be established; however, evidence is accumulating that in addition to leak pathways a specific K+ channel or...

In addition to irrigation, other viticultural practices such as soil management can be applied improve grapevine (Vitis vinifera L.) quality responses and attenuate unfavourable environmental conditions. Cover crops in the interrow of irrigated vineyards change dynamics water extraction it is expected that patterns vines’ relations will modified, also changing their productive responses. This s...