The European Space Agency (ESA) Short-Arm Centrifuge (SAHC) was used to generate 0.7, 1, and 1.2 Gz of artificial gravity at the level of the heart in 6 healthy male subjects. We investigated the hypothesis that the effects of hyper-gravity on Respiratory Sinus Arrhythmia (RSA) can mimic the effects observed after spaceflight cardiovascular deconditioning. Artificial gravity along the head-to-f...

BACKGROUND The most commonly observed pathology in chest traumas is rib fracture, and the most important clinical symptom is severe pain. AIMS To investigate the effectiveness of intramuscular opioid (IMO), intravenous patient-controlled analgesia (IVPCA) and the Fentanyl transdermal therapeutic system (TTS) in the management of rib fracture pain. STUDY DESIGN Prospective randomized clinica...

Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is highly refractory to all current immune checkpoint blockade (ICB) therapies and display limited CD8 +T cell infiltration. We previously showed that deficiency of P-selectin glycoprotein 1 (PSGL-1) promotes responses clear chronic lymphocytic choriomeningitis virus (LCMV) Cl13 infection dramatically inhibits the growth anti-PD-1 res...

Abstract Aim To investigate the association between post-pandemic activity levels and day-case rates for laparoscopic cholecystectomies in England. Method We examined data from HES (Hospital Episode Statistics) on adult elective period January 2019 to September 2022 (inclusive). Activity first six months of were compared whole (the baseline). Day-case was identified where length stay record zer...

Round output diierence input diierence p icb key fraction P = (f7g; 0) 1 A = 0 a = 0 1 1 2 B = f45g b = f7g p = 1=8 0 1/2 3 C = f6g c = f45g p = 1=8 1 1/2 4 f45g f6; 7g p = 1=8 0 1/2 5 0 0 1 1 6 f45g f6; 7g p = 1=8 0 1/2 7 f6g f45g p = 1=8 1 1/2 8 f45g f7g p = 1=8 0 1/2 9 0 0 1 1 8 f39g f7g p = 1=8 1 1/2 9 f7g f39g p = 1=8 1 1/2 T = (0; f39g) 17 ent fractions of the key space. Round output diie...

Abstract Background Immunotherapy is a revolutionary strategy in cancer therapy, but the resistance of which one important challenges. Detecting regulation immune cells and biomarkers concerning checkpoint blockade (ICB) therapy great significance. Methods Here, we firstly constructed networks for 11 cell clusters by integrating biological pathway data single sequencing metastatic melanoma with...

Abstract Compliant mechanisms (CMs) have presented its inherently advantageous properties due to the fact that CMs utilize elastic deformation of elementary flexible members transfer motion, force, and energy. Previously, classic Euler–Bernoulli beam theory is most used in terms modeling large deflections CMs. However, it has some assumptions may decrease accuracy, such as ignoring shear strain...

This study was aimed at developing a method for measuring the relationship between intellectual capital and project manager competencies. Intellectual capital consist human capital, structural capital and relational capital. Project manager competencies have been evaluated based on IPMA Competence Baseline (ICB) and Project Manager Competency Development Framework (PMCDF) includes knowledge, sk...