Intracerebral hemorrhage (ICH) is a common and often fatal subtype of stroke and produces severe neurological deficits in survivors. At present, there is lack of effective treatments that improve outcome in ICH. A neglected aspect of ICH research is the development of approaches that can be effectively used to improve recovery. Although previous studies have showed that thrombin induces blood-b...

Background: Stroke is a leading causes of death and disability globally and 10-15% of all strokes are caused by intracerebral hemorrhage (ICH). An increased knowledge of factors affecting prognosis after ICH is needed to guide the development of possible interventions to improve outcome. Aim: To investigate how clinical andimaging factors affect survival and functional outcome after ICH and how...

Multiple studies have addressed deep vein thrombosis chemoprophylaxis timing in traumatic brain injuries. However, a precise time for safe and effective chemoprophylaxis is uncertain according to experts. A comprehensive literature review on brain injuries was performed to delineate temporal proportions for 1) spontaneous intracranial hemorrhage (ICH) progression, 2) post-chemoprophylaxis ICH e...

the method has been developed and validated for the determination of hydroquinone in liposomal formulation. the samples were dissolved in methanol and evaluated in 293 nm. the validation parameters such as linearity, accuracy, precision, specificity, limit of detection (lod) and limit of quantitation (loq) were determined. the calibration curve was linear in 1-50 µg /ml range of hydroquinone an...

BACKGROUND AND PURPOSE Intracerebral hemorrhage (ICH) has a 30-day mortality rate of 40% to 50% and lacks a proven treatment. We report a preplanned, midpoint analysis of the first population-based, case-control study that examines both genetic and environmental risk factors of ICH. METHODS We prospectively identified cases of hemorrhagic stroke at all 16 hospitals in the Greater Cincinnati/N...

The second Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT II)1 randomized 2,839 patients with intracerebral hemorrhage (ICH) within 6 h of symptom onset to intensive systolic blood pressure (SBP) reduction, with a target of <140 mm Hg within 1 h, or guideline-recommended SBP reduction, with a target of <180 mm Hg using a variety of antihypertensive medications. ...

Two approaches of multiple decision processes are proposed for unifying the non-inferiority, equivalence and superiority tests in a comparative clinical trial for a new drug against an active control. One is a method of confidence set with confidence coefficient 0.95 improving the conventional 0.95 confidence interval in the producer's risk and also the consumer's risk in some cases. It require...

BACKGROUND AND PURPOSE Our previous studies have demonstrated that oxidative DNA injury occurs in the brain after intracerebral hemorrhage (ICH). We therefore examined whether edaravone, a free-radical scavenger, could reduce ICH-induced brain injury. METHODS These experiments used pentobarbital-anesthetized, male Sprague-Dawley rats that received an infusion of either 100 microL autologous w...