Within this survey article, we explain real-time symbolic timing diagrams and the ICOS toolbox supporting timing-diagram-based requirements capture and rapid prototyping. Real-time symbolic timing diagrams are a full-edged metric-time temporal logic, but with a graphical syntax reminiscent of the informal timing diagrams widely used in electrical engineering. ICOS integrates a variety of tools,...

A method for the practical determination of the absolute concentration of single (a1delta(g)) oxygen is discussed. The method is based on sensitive off-axis integrated-cavity-output spectroscopy (ICOS). Off-axis ICOS allows narrowband, continuous-wave lasers to be used in conjunction with optical cavities to record sensitive absorption measurements. The details of the method as well as spectros...

Abstract. Stratospheric HCl observations are an important diagnostic for the evaluation of catalytic processes that impact ozone layer. We report here in situ balloon-borne employing off-axis integrated cavity output spectrometer (OA-ICOS) fitted with a reinjection mirror. Laboratory assessments demonstrated has 90 % response time 10 s to changes and 30 precision 26 pptv. The instrument was dep...

10-74 David Badesch, MD Dr. Badesch has received honoraria for service on steering committees or advisory boards (or as a consultant) to the following companies working in the area of pulmonary hypertension: Actelion/CoTherix, Gilead/Myogen, Encysive, Pfizer, Mondo-Biotech/Mondogen, Biogen IDEC, United Therapeutics/Lung Rx, GlaxoSmithKline, Lilly/ICOS, Bayer, Ikaria, and Arena. He has received ...

Research summary We apply insights from research in social psychology and labor economics to the domain of entrepreneurial finance investigate how founder chief executive officers' (founder CEOs') facial attractiveness influences firm valuation. Leveraging novel context initial coin offerings (ICOs), we document a pronounced CEO beauty premium, with positive relationship between find only very ...

Regulatory T cells (Tregs), a subset of CD4(+) T cells, dramatically accumulate with age in humans and mice and contribute to age-related immune suppression. Recently, we showed that a majority of accumulating Tregs in aged mice expressed low levels of CD25, and their accrual is associated with declining levels of IL-2 in aged mice. In this study, we further investigated the origin of CD25(lo) ...

BACKGROUND Graft-vs-host disease (GVHD) is a major complication of allogenic bone marrow transplantation (BMT). Targeting costimulatory molecules with antagonist antibodies could dampen the excessive immune response that occurs, while preserving the beneficial graft vs leukemia (GVL) of the allogeneic response. Previous studies using a mouse model of GVHD have shown that targeting the T-cell In...

background: atherosclerosis is a multifactorial disorder with chronic inflammatory conditions in which immune cells play a significant role in its pathogenic process. regulatory t cells (treg), as a part of immune system, are involved in controlling autoimmune and inflammatory diseases. quantitative and/or functional alteration of tregs has been shown to play an atheroprotective role and may al...