During the development of the somatic genome from the Paramecium germline genome the bulk of the copies of ∼45 000 unique, internal eliminated sequences (IESs) are deleted. IES targeting is facilitated by two small RNA (sRNA) classes: scnRNAs, which relay epigenetic information from the parental nucleus to the developing nucleus, and iesRNAs, which are produced and used in the developing nucleu...

Thousands of single-copy internal eliminated sequences (IESs) are excised from the germ line genome of ciliates during development of the polygenomic somatic macronucleus, following sexual events. Paramecium IESs are short, noncoding elements that frequently interrupt coding sequences. No absolutely conserved sequence element, other than flanking 5'-TA-3' direct repeats, has been identified amo...

BACKGROUND As malaria control is intensified, pregnant women may be less exposed to malaria, thus affecting the acquisition of protective antibody. METHODS Plasma samples were collected from Malawian and Papua New Guinean (PNG) pregnant women enrolled over 7-year periods, during which malaria prevalence fell by over two thirds. Immunoglobulin G (IgG) levels to schizont extract, merozoite anti...

The excision of internal eliminated sequences (IESs) from the germline micronuclear DNA occurs during the differentiation of a new macronuclear genome in ciliated protozoa. In Paramecium, IESs are generally short (28-882 bp), AT rich DNA elements that show few conserved sequence features with the exception of an inverted-terminal-repeat consensus sequence that has similarity to the ends of mari...

BACKGROUND Psychological distress caused by cardiovascular pre-participation screening (PPS) may be a reason not to implement a PPS program. We assessed the psychological impact of PPS, including cardiac computed tomography (CT), in 318 asymptomatic sportsmen aged ≥45 years. METHODS Coronary artery disease (CAD) was defined as a coronary artery calcium score ≥100 Agatson units and/or ≥50% lum...

Abstr act. This paper st udies differences and similarit ies among inductive GMDH, deductive adaline, and back prop agat ion techniques. All these are considered as parallel opt imizat ion algorithms because each one minimizes the out put residual error in its own way. Selforganizing processes and criteria that help obta in the optimum output responses in the algorithms are explained through th...

This article’s main objective was to present a model for measuring research capacity from an intellectual capital-based approach for Colombian higher education institutions ( Instituciones de Educación Superior – IES), forming part of the national science and technology system, in the sense that around 90% of Colombian research groups belong to it. The model should lead to identifying IES capac...

We study additive representability of orders on multisets (of size k drawn from a set of size n) which satisfy the condition of Independence of Equal Submultisets (IES) introduced by Sertel and Slinko (2002, 2007). Here we take a geometric view of those orders, and relate them to certain combinatorial objects which we call discrete cones. Following Fishburn (1996) and Conder and Slinko (2004), ...

Intuitive eating is characterized by eating based on physiological hunger and satiety cues rather than situational and emotional cues and is associated with psychological well-being. This study reports on the development and initial psychometric evaluation of the Intuitive Eating Scale (IES) with data collected in 4 studies from 1,260 college women. Exploratory factor analysis uncovered 3 facto...

This study examined health/mental health status, family functioning, and resiliency among a sample of bereaved parents (N = 503). Participants were recruited from an online support community to complete an online survey instrument (response rate = 51.75%). The questionnaire contained an array of self-report instruments, such as the Hopkins Symptoms Checklist-25 (HSCL-25), the Impact of Event Sc...