نتایج جستجو برای: ift
تعداد نتایج: 953 فیلتر نتایج به سال:
WD60/FAP163 is a dynein intermediate chain required for retrograde intraflagellar transport in cilia
Retrograde intraflagellar transport (IFT) is required for assembly of cilia. We identify a Chlamydomonas flagellar protein (flagellar-associated protein 163 [FAP163]) as being closely related to the D1bIC(FAP133) intermediate chain (IC) of the dynein that powers this movement. Biochemical analysis revealed that FAP163 is present in the flagellar matrix and is actively trafficked by IFT. Further...
Primary cilia are microtubule-based organelles that have important sensory functions. For their function, cilia rely on the delivery of specific proteins, both by intracellular trafficking and intraflagellar transport (IFT). In the cilia of Caenorhabditis elegans, anterograde IFT is mediated by kinesin-II and OSM-3. Previously, we have shown that expression of a dominant active G protein α subu...
Cilia length and function are dynamically regulated by modulation of intraflagellar transport (IFT). The cilia of C. elegans amphid channel neurons provide an excellent model to study this process, since they use two different kinesins for anterograde transport: kinesin-II and OSM-3 kinesin together in the cilia middle segments, but only OSM-3 in the distal segments. To address whether sensory ...
While cilia are present on most cells in the mammalian body, their functional importance has only recently been discovered. Cilia formation requires intraflagellar transport (IFT), and mutations disrupting the IFT process result in loss of cilia and mid-gestation lethality with developmental defects that include polydactyly and abnormal neural tube patterning. The early lethality in IFT mutants...
The earliest clinical sign of esophageal atresia (EA) is excessive salivation and the diagnosis is made by failure to pass an infant feeding tube (IFT) into the stomach. The diagnostic errors may occur due to presence of an unusually long upper pouch, when the IFT seems to pass into the stomach. We describe one such case and review the relevant literature.
Smoking and COPD are associated with decreased mucociliary clearance, and healthy smokers have shorter cilia in the large airway than nonsmokers. We hypothesized that changes in cilia length are consistent throughout the airway, and we further hypothesized that smokers with COPD have shorter cilia than healthy smokers. Because intraflagellar transport (IFT) is the process by which cilia of norm...
This paper presents a new methodology for fault diagnosis, based on the natural hierarchy of components and sub-components in electrical and/or mechanical systems. In the first section, the advantages of hierarchically decomposing learning tasks are discussed. In the second section, the author’s fault diagnosis system, DE/ IFT, is introduced. The underlying algorithm, the training cycle and the...
Current cognitive models of Web navigation (e.g., Information Foraging Theory, IFT, Pirolli, 2007) are based on the assumption that users’ behavior is guided by evaluating the topical relevance of information encountered on the Web. This “information scent” has been successfully used to model Web search behavior. In this paper, however, we claim that topicality-oriented theories like IFT need t...
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