PURPOSE During development of the nervous system, neuronal migration and axonal growth depend on specific interactions with molecules in the extracellular matrix. In a recent study of laminin expression, it was shown that laminin B1 mRNA was expressed by both nonneural cells and the retinal ganglion cells during development of the mouse retina. Because collagen IV is associated with laminin in ...

Aims: To report on the use of trypan blue (TB) 0.06% for staining the internal limiting membrane (ILM) and epiretinal membrane (ERM) during vitrectomy and report on their histology. Method: 14 consecutive patients with idiopathic macular hole or macular pucker (seven patients each) were prospectively recruited for ILM or ERM peel respectively. After pars plana vitrectomy and induction of poster...

PURPOSE The aim of this study was to evaluate risk factors for the anatomical and functional outcomes of macular hole (MH) surgery with special emphasis on the experience of the surgeon. METHODS A total of 225 surgeries on idiopathic MHs (IMHs) performed by 6 surgeons with a mean follow-up period of 20.5 months were reviewed in this retrospective study. Outcome parameters focused on IMH closu...

PURPOSE To evaluate the efficacy of a combined macular buckle under direct vision and 23-gauge pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling in refractory macular hole retinal detachment (MHRD) with extreme high axial myopia. DESIGN Prospective, randomised controlled study. PARTICIPANTS The study included 98 eyes of 98 patients of MHRD with extreme high axial (>3...

AIMS To determine the surgical outcome of indocyanine green (ICG) assisted retinal internal limiting membrane (ILM) peeling in macular hole surgery for severely myopic eyes and compare the visual and anatomical outcomes with an emmetropic control group. METHODS 10 severely myopic eyes (-6.0 D or greater) of 10 patients with macular holes without retinal detachment were recruited prospectively...

BACKGROUND The opinion of application of indocyanine green (ICG) in the macular hole surgery was contradictory. Here we conducted a meta-analysis to evaluate the effect of in internal limiting membrane (ILM) peeling for macular hole surgery. METHODS AND FINDINGS We searched electronic databases for comparative studies published before July 2012 of ILM peeling with and without ICG. Twenty-two ...

In this paper, we develop a toolkit to derive principles for the interpetability logic of all reasonable theories by fine-tuning ILM and ILP proofs.