Objective: The purpose of the present study was to investigate the penicillin binding proteins (PBPs), drug influx and efflux modulations during heat stress and their effects on the bactericidal action of imipenem on non-typeable Haemophilus influenzae (NTHi). Methods: The two NTHi clinical isolates (GE47 and GE88, imipenem MICs by E-test > 32 μg/mL) examined in this study were collected at Gen...

Biapenem is a carbapenem being developed in combination with RPX7009, a new inhibitor of serine β-lactamases. Biapenem was tested alone and in combination with fixed concentrations of RPX7009 by agar dilution against 377 recent isolates of anaerobes. A separate panel of 27 isolates of Bacteroides spp. with decreased susceptibility or resistance to imipenem was also tested. Comparator drugs incl...

BACKGROUND The systemic surveillance of imipenem-resistant Acinetobacter baumannii (IRAB) from multicenters in Taiwan revealed the emergence of isolates with bla(OXA-72). This study described their genetic makeup, mechanism of spread, and contribution to carbapenem resistance. METHODS Two hundred and ninety-one non-repetitive isolates of A. baumannii were collected from 10 teaching hospitals ...

Carbapenem resistance was studied in two sets of Citrobacter freundii strains: (i) strain CFr950, resistant to imipenem (MIC, 16 microg/ml) and isolated in vivo during imipenem therapy, and strain CFr950-Rev, the spontaneous, imipenem-susceptible revertant of CFr950 selected in vitro, and (ii) strains CFr801 and CFr802, two imipenem-resistant mutants selected in vitro from the susceptible clini...

Beta-lactams are regularly administered in intermittent short-term infusions. The percentage of the dosing interval during which free drug concentrations exceed the MIC (fT(>MIC)) is the measure of drug exposure that best correlates with clinical outcome for beta-lactams. Therefore, administration by continuous infusion has gained increasing interest recently. We studied 20 critically ill patie...

conclusions our results showed the rate of effects of different risk factors on imipenem resistance. regarding the studied risk factors, appropriate programs must be set in place to control and prevent imipenem resistance in gram-negative bacteria. results of the 374 isolated, 134 were imipenem resistant, and 240 were sensitive to imipenem. the resistance rate was more common in males and in pa...

background :   imipenem-resistant gram negative bacteria, resulting from metallo-beta-lactamase (mbls)-producing strains have been reported to be among the important causes of nosocomial infections and of serious therapeutic problem worldwide. because of their broad range, potent carbapenemase activity and resistance to inhibitors, these enzymes can confer resistance to almost all beta-lactams....

background :    acinetobacter baumannii has become one of the most important causes of nosocomial infections in recent years. the organism seems to be resistant to most classes of antibiotics. carbapenems are considered the most effective drugs for treatment of these infections. however, increasing emergence of carbapenem resistant a. baumannii has become a major healthcare problem.   methods :...

background : these days, the antibiotic resistance of pseudomonas aeruginosa isolates to imipenem has significantly increased. therefore the study of resistance to imipenem in this organism to imipenem in determining the appropriate treatment is crucial and necessary. the goal of this study is to compare three phenotypic methods of e-test, disk diffusion and micro broth dilution in the study of...